What Is the Impact of Atrial Fibrillation on the Clinical Course of Hypertrophic Cardiomyopathy?
Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with hypertrophic cardiomyopathy (HCM), with a reported prevalence ranging from 10% to 28% [1–13]. In a recent study involving 480 patients with HCM followed up at two institutions for over 9 years, AF was documented in 22% of patients, with an incidence of 2% new cases per year . Comparison with the general population shows that the likelihood of developing AF is 4–6 times in HCM patients at any given age. AF became progressively more common with age in HCM patients, and particularly after the age of 60 years; the mean age at onset of the arrhythmia was 54 years for paroxysmal AF and 57 years for chronic AF . However, over one–third of patients with AF developed their arrhythmia before the age of 50 years, and these patients were at greater risk of clinical deterioration and HCM-related death than were patients with AF onset later in life . Finally, postoperative AF occurred following surgical septal myectomy in approximately 30% of patients in one series .
KeywordsAtrial Fibrillation Hypertrophic Cardiomyopathy Atrial Fibrillation Patient Postoperative Atrial Fibrillation Trophic Cardiomyopathy
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