What Is the Best Practical Scheme for Initiating Oral Anticoagulant Treatment in Outpatients with Atrial Fibrillation?
Patients with atrial fibrillation (AF) have an approximately four-fold increased risk of stroke and systemic embolism . Generally thrombus forms in the left atrial appendage because of the relative inactivity of the atria during AF . The risk of stroke exists in all patients with AF, but the incidence of stroke is related to coexistent cardiovascular disease, hypertension, diabetes, or previous stroke [3,4]. Advancing age is associated with increased stroke risk, probably due to the effect of left atrium enlargement and left ventricular diastolic dysfunction, frequently observed in elderly patients [5, 6], Nearly half of AF- associated strokes occur in patients older than 75 years.
KeywordsAtrial Fibrillation International Normalize Ratio Stroke Prevention Systemic Embolism Left Atrial Appendage
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