Which Is the Ideal Drug for Chronic Prophylaxis of Atrial Fibrillation?

  • G. Boriani
  • M. Biffi
  • I. Diemberger
  • C. Martignani
  • C. Camanini
  • C. Valzania
  • G. Domenichini
  • I. Corazza
  • A. Branzi
Conference paper


A series of antiarrhythmic agents have been demonstrated to be highly effective in terminating recent-onset atrial fibrillation, class IC agents being the most effective [1, 2]. In contrast with the high efficacy shown in treating recent-onset atrial fibrillation, results obtained in preventing recurrences of atrial fibrillation are scanty [3–6]. Table 1 summarizes reported data from the literature. As shown, the percentage of patients who maintain sinus rhythm without arrhythmia recurrence under placebo treatment is around 30% after 3–6 months and around 20%–25% after 12 months. Antiarrhythmic agents may increase the percentage of patients who maintain sinus rhythm, but the overall efficacy is limited and, except for amiodarone, no more than 50% of the treated patients are free from arrhythmia recurrences after 6–12 months. For amiodarone, efficacy rates of 75%–78.5% at 6 months and of 50%–73% at 12 months have been reported.


Atrial Fibrillation Sinus Rhythm Atrial Flutter Paroxysmal Atrial Fibrillation Persistent Atrial Fibrillation 
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Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • G. Boriani
    • 1
  • M. Biffi
    • 1
  • I. Diemberger
    • 1
  • C. Martignani
    • 1
  • C. Camanini
    • 1
  • C. Valzania
    • 1
  • G. Domenichini
    • 1
  • I. Corazza
    • 1
  • A. Branzi
    • 1
  1. 1.Institute of CardiologyUniversity of BolognaItaly

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