Imaging the Effects of Systemic Metabolic Diseases on the Brain
Brain function depends on a consistent supply of oxygen and glucose. Many systemic disorders that interfere with the metabolism of these two substances result in neurological dysfunction. The brain is commonly affected by disorders primarily involving the heart, liver, kidneys, blood, and endocrine organs. Most cardiac disorders result in ischemic brain damage and are not addressed here. The most common liver disorders to affect the brain are those resulting in acute and chronic hepatic failure. The central nervous system (CNS) is also affected by disorders of the metabolism of elemental substances such as salts and metals. The most common disorders in this category involve those related to copper, sodium, and iron metabolism. CNS injuries may also result from extraneous substances, either toxic or those used as medications. Substances toxic to the CNS include carbon monoxide, glycol, lead, methanol, mercury, and toluene. In this paper, I also address miscellaneous disorders including hypoglycemia, anorexia nervosa, chronic fatigue syndrome, porphyria and amyloidosis and their effects on the CNS. CNS disorders may also be associated with gastrointestinal disorders.
KeywordsAnorexia Nervosa Chronic Fatigue Syndrome Magnetic Resonance Imaging Finding Magnetic Resonance Imaging Abnormality Centrum Semiovale
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