The Relevance of Normal-Appearing White Matter Pathology in Multiple Sclerosis

  • M. MacInnes
  • D. L. Arnold
Part of the Topics in Neuroscience book series (TOPNEURO)


Although the current dogma is that multiple sclerosis (MS) is a T-cell-mediated inflammatory demyelinating disease, a number of studies have provided evidence to challenge this concept. Data obtained through the use of MR techniques such as magnetic resonance spectroscopy (MRS) and magnetization transfer imaging support the argument that MS could be primarily a degenerative disease in which focal inflammatory lesions occur secondarily. This chapter will focus on some of the evidence that supports this concept.


Multiple Sclerosis Multiple Sclerosis Patient Magnetic Resonance Spectroscopy Expand Disability Status Scale Magnetization Transfer 
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© Springer-Verlag Italia 2004

Authors and Affiliations

  • M. MacInnes
  • D. L. Arnold

There are no affiliations available

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