Diffusion-Weighted Imaging of the Normal-Appearing White Matter in Multiple Sclerosis

  • M. Rovaris
  • M. Filippi
Part of the Topics in Neuroscience book series (TOPNEURO)


Conventional magnetic resonance (MR) imaging (MRI) is widely used for the diagnosis of multiple sclerosis (MS), because of its ability to demonstrate the presence of central nervous system (CNS) lesions with dissemination in space and time [1]. In addition, when monitoring the evolution of MS, serial brain MRI scans may disclose the occurrence of disease activity and the accumulation of disease burden with a greater sensitivity than the clinical assessment of relapses and neurological disability. Nevertheless, since a clear discrepancy between clinical and conventional MRI findings in patients with established MS has emerged from most of the available studies [2], there is an urgent need for more accurate neuroimaging techniques to monitor MS evolution.


Multiple Sclerosis Apparent Diffusion Coefficient Fractional Anisotropy Expand Disability Status Scale Magn Reson Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • M. Rovaris
  • M. Filippi

There are no affiliations available

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