Measuring and Interpreting White Matter Volume Changes in Multiple Sclerosis

  • C. Wegner
  • S. Smith
  • P. M. Matthews
Part of the Topics in Neuroscience book series (TOPNEURO)


Neuronal and axonal degeneration have become recognized as major elements in the pathology of multiple sclerosis (MS). Interest has developed in monitoring these events in vivo with the recognition that they are closely coupled to development of disability [1]. A compelling question at present is the extent to which these phenomena are linked to the predominantly T-cell-mediated inflammatory changes in white matter (“plaques”), hitherto believed to be the pathological hallmark of MS.


Multiple Sclerosis White Matter Brain Volume Brain Atrophy Axonal Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • C. Wegner
  • S. Smith
  • P. M. Matthews

There are no affiliations available

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