Functional MRI in Multiple Sclerosis

  • M. Filippi
  • M. A. Rocca
Part of the Topics in Neuroscience book series (TOPNEURO)


During the last decade, important efforts have been devoted to improving our understanding of the pathophysiology of multiple sclerosis (MS), with the ultimate goal of identifying and monitoring treatment strategies with the potential to modify the evolution of the disease favorably. One of the major results of this increased research interest in MS is that the classical notion of MS as a demyelinating disease affecting the white matter of the central nervous system (CNS) has been challenged significantly. First, it became apparent that axonal pathology in macroscopic brain lesions and normal-appearing brain tissue (NABT) is an important aspect of the disease from its earliest phases [1–3]. Second, it was shown that grey matter is not spared by the disease [4–10]. Finally, brain plasticity is now considered an important factor which might contribute to the clinical recovery and the maintenance of a normal level of function in the presence of irreversible axonal/neuronal loss.


Multiple Sclerosis Multiple Sclerosis Patient Optic Neuritis Mean Diffusivity Supplementary Motor Area 
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Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • M. Filippi
  • M. A. Rocca

There are no affiliations available

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