The Grey Matter Component of MS Pathology: Magnetization Transfer and Diffusion-Weighted Imaging

  • M. A. Rocca
  • M. Filippi
Part of the Topics in Neuroscience book series (TOPNEURO)


The classical view of multiple sclerosis (MS) as a chronic inflammatory disease affecting the white matter (WM) of the central nervous system (CNS) has been recently challenged by pathological studies and by the extensive application of modern magnetic resonance imaging (MRI)-based techniques, including magnetization transfer (MT) MRI and diffusion-weighted (DW) MRI. These techniques have overcome some of the limitations of conventional MRI, such as its poor specificity to the heterogeneous pathological substrates of the disease, and have demonstrated that: (1) axonal pathology in macroscopic brain lesions and in normal-appearing brain tissue is an important feature of MS from its earliest phase; (2) grey matter (GM) is not spared by the pathological process in MS; and (3) brain plasticity might contribute to clinical recovery and the maintenance of a normal level of function in the presence of MS-related irreversible tissue loss.


Multiple Sclerosis Multiple Sclerosis Patient Expand Disability Status Scale Mean Diffusivity Conventional Magnetic Resonance Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Italia 2004

Authors and Affiliations

  • M. A. Rocca
  • M. Filippi

There are no affiliations available

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