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Imaging Cerebral Grey Matter Volume in Multiple Sclerosis

  • N. De Stefano
Chapter
Part of the Topics in Neuroscience book series (TOPNEURO)

Abstract

Axonal and neuronal pathology have recently been increasingly regaining attention in multiple sclerosis (MS). There has been a shift in focus from considering functional impairment as primarily resulting from changes in the electrical conduction properties of axons after demyelination, towards an appreciation of the apparently primary role of neurodegeneration in the pathogenesis of this disease. Brain atrophy, which constantly occurs and progressively increases in MS patients, has greatly contributed to the development of this concept. As an expression of general tissue loss, brain atrophy is generally considered a global marker of adverse disease outcome. This seems to include, even in a primarily demyelinating disease such as MS, grey matter (GM) tissue abnormality. Accordingly, selective pathology in the cerebral GM has been shown in recent post-mortem [1–3] and in vivo [4–9] MS studies suggesting that neocortical pathology is more relevant in MS than previously thought.

Keywords

Multiple Sclerosis White Matter Lesion Brain Atrophy Grey Matter Atrophy Brain Volume Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Italia 2004

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  • N. De Stefano

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