Growth and Puberty in Hydrocephalus

  • Rasa Brauner
  • Florence Cholley
  • Christine Trivin


Non-tumor-related hydrocephalus may cause short adult height [21, 26], weight gain [11] and/or disorders of puberty [4a, 7, 10, 12]. Although these conditions are believed to be caused by increased pressure on the hypothalamic-pituitary (HP) area of the brain, the exact mechanism is unknown. We will analyze: (1) the expression and incidence of each of these disorders, and their relationship to the quality of the control of the hydrocephalus; (2) the special features of hydrocephalus attributable to a suprasellar arachnoid cyst; and (3) the management of growth and puberty in patients with hydrocephalus.


Growth Hormone Secretion Arachnoid Cyst Adult Height Precocious Puberty Central Precocious Puberty 


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  1. 1.
    Adan L, Souberbielle JC, Zucker JM, Pierre-Kahn A, et al: Adult height in 24 patients treated for growth hormone deficiency and early puberty. J Clin Endocrinol Metab 89: 229–233, 1997CrossRefGoogle Scholar
  2. 2.
    Adan L, Bussières L, Dinand V, Zerah M, et al: Growth, puberty, and hypothalamic-pituitary function in children with suprasellar arachnoid cyst. Eur J Pediatr, 159:348–355, 2000PubMedCrossRefGoogle Scholar
  3. 3.
    Bercovici JP, Besson G, Caroff J: Puberté précoce, kyste arachnoidien du 3e ventricule et acétate de cyproterone. Ann Endocrinol 37:467–468, 1976Google Scholar
  4. 4.
    Bussières L, Souberbielle JC, Pinto G, Adan L, et al: The use of insulin-like growth factor I reference values for the diagnosis of growth hormone deficiency in prepubertal children. J Endocrinol 52:735–739, 2000Google Scholar
  5. 4a.
    Cholley F, Trivin C, Sainte-Rose C, Souberbielle JC, Cinalli G, Brauner R: Disorders of growth and puberty in children with non-tumoral hydrocephalus. J Pediatr Endocrinol Metab 14:319–327, 2001PubMedCrossRefGoogle Scholar
  6. 5.
    Clark SJ, Van Dop C, Conte FA, Grumbach MM, et al: Reversible true precocious puberty secondary to a congenital arachnoid cyst. Am J Dis Child 142:255–256, 1988PubMedGoogle Scholar
  7. 6.
    Dos Santos FM, Campistol J, Ruscalleda J, Fernandez-Alvarez E: Quiste aracnoideo parasellar asociado a pubertad precoz isosexual. An Esp Pediatr 18:141–144, 1983Google Scholar
  8. 7.
    Elias ER, Sadeghi-Nejad A: Precocious puberty in girls with myelodysplasia. Pediatrics: 521–522, 1994Google Scholar
  9. 8.
    Fontoura M, Brauner R, Prevot C, Rappaport R: Precocious puberty in girls: early diagnosis of a slowly progressing variant. Arch Dis Child 64:1170–1176, 1989PubMedCrossRefGoogle Scholar
  10. 9.
    Hoffman HJ, Brice Hendrick E, Humphreys RP, Armstrong EA: Investigation and management of suprasellar arachnoid cysts. J Neurosurg 57:597–602, 1982PubMedCrossRefGoogle Scholar
  11. 10.
    Hochhaus F, Butenandt O, Schwarz HP, Ring-Mrozik E: Auxological and endocrinological evaluation of children with hydrocephalus and/or meningomyelocele. Eur J Pediatr 156:597–601, 1997PubMedCrossRefGoogle Scholar
  12. 11.
    Löppönen T, Saukkonen A-L, Serlo W, Lanning P, Knip M: Slow prepubertal linear growth but early pubertal growth spurt in patients with shunted hydrocephalus. Pediatrics 95:917–923, 1995PubMedGoogle Scholar
  13. 12.
    Löppönen T, Saukkonen A-L, Serlo W, Tapanainen P, et al: Accelerated pubertal development in patients with shunted hydrocephalus. Arch Dis Child 74:490–496, 1996PubMedCrossRefGoogle Scholar
  14. 13.
    Löppönen T, Pääkkö E, Laitinen J, Saukkonen A-L, et al: Pituitary size and function in children and adolescents with shunted hydrocephalus. Clin Endocrinol 46: 691–699, 1997CrossRefGoogle Scholar
  15. 14.
    Marshall WA, Tanner JM: Variations in the pattern of pubertal changes in girls. Arch Dis Child 44:291–303, 1969PubMedCrossRefGoogle Scholar
  16. 15.
    Marshall WA, Tanner JM: Variations in the pattern of pubertal changes in boys. Arch Dis Child 45:13–23, 1970PubMedCrossRefGoogle Scholar
  17. 16.
    Mori K: Precocious puberty with fits of laughter and with a large cystic mass on the floor of the third ventricle. Arch Jpn Chir 38: 800–804, 1969Google Scholar
  18. 17.
    Obenchain TG, Becker DP: Head bobbing associated with a cyst of the third ventricle. J Neurosurg 37:457–459, 1972PubMedCrossRefGoogle Scholar
  19. 18.
    Okamoto K, Nakasu Y, Sato M, Handa J: Isosexual precocious puberty associated with multilocular arachnoid cysts at the cranial base. Report of a case. Acta Neurochirur 57:87–89, 1981CrossRefGoogle Scholar
  20. 19.
    Pierre-Kahn A, Capelle L, Brauner R, Sainte-Rose C, et al: Presentation and management of suprasellar arachnoid cysts. J Neurosurg 73:355–359, 1990PubMedCrossRefGoogle Scholar
  21. 20.
    Proos LA, Dahl M, Ahlsten G, Tumevo T, Gustafsson J: Increased perinatal intracranial pressure and prediction of early puberty in girls with myelomeningocele. Arch Dis Child 75:42–45, 1996PubMedCrossRefGoogle Scholar
  22. 21.
    Rotenstein D, Adams M, Reigel DH: Adult stature and anthropomorphic measurements of patients with myelomeningocele. Eur J Pediatr 154:398–402, 1995PubMedCrossRefGoogle Scholar
  23. 22.
    Segall HD, Hassan G, Ling SM, Carton C: Suprasellar cysts associated with isosexual precocious puberty. Radiology 111:607–616, 1974PubMedGoogle Scholar
  24. 23.
    Shepherd K, Roberts D, Golding S, Thomas BJ, Shepherd RH: Body composition in myelomeningocele. Am J Clin Nutr 53:1–6, 1991PubMedGoogle Scholar
  25. 24.
    Sweasey TA, Venes JL, Hood TW, Randall JB: Stereotactic decompression of a prepontine arachnoid cyst with resolution of precocious puberty. Pediatr Nerosci 15:44–47, 1989CrossRefGoogle Scholar
  26. 25.
    Tanner JM, Whitehouse RH., Marubini E, Resele LF: The adolescent growth spurt of boys and girls of the Harpenden growth study. Ann Hum Biol 3:109–126, 1976PubMedCrossRefGoogle Scholar
  27. 26.
    Trollmann R, Dörr HG, Strehl E, Katalinic A, et al: Growth and pubertal development in patients with meningomyelocele: a retrospective analysis. Acta Paediatr 85:76–80, 1996PubMedCrossRefGoogle Scholar
  28. 27.
    Trollmann R, Strehl E, Dörr HG: Growth hormone deficiency in children with myelomeningocele (MMC) — effects of growth hormone treatment. Eur J Pediatr Surg 7,Suppl 1:58–59, 1997PubMedGoogle Scholar
  29. 28.
    Trollmann R, Strehl E, Dörr HG: Precocious puberty in children with myelomeningocele: treatment with gonadotropin-releasing hormone analogues. Dev Med Child Neurol 40:38–43, 1998PubMedCrossRefGoogle Scholar
  30. 29.
    Turgut M, Ekin Ozean OE: Suprasellar arachnoid cyst as a cause of precocious puberty and bobble-head doll phenomenon. Eur J Pediatr 151:76, 1992PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2005

Authors and Affiliations

  • Rasa Brauner
    • 1
  • Florence Cholley
    • 1
  • Christine Trivin
    • 2
  1. 1.Université René DescartesParisFrance
  2. 2.Physiology LaboratoryHôpital Necker-Enfants Malades, Assistance Publique — Hôpitaux de ParisParisFrance

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