Cerebrospinal Fluid Dynamics

  • Marek Czosnyka
  • Zofia H. Czosnyka
  • Peter C. Whitfield
  • John D. Pickard


Historically, the saga of cerebrospinal fluid (CSF) dynamics almost always starts with the Monro-Kellie doctrine. This states that the sum of volumes of brain, blood and CSF (although in the time of Kellie, i.e. the early nineteenth century, the volume of CSF was not considered) must be constant due to the fixed volume of the skull and spinal canal. This may be expressed mathematically as:
$$Volumeofbrain + volumeofblood + + volumeofCSF = const$$


Cerebral Blood Flow Cerebral Blood Volume Infusion Test Normal Pressure Hydrocephalus Compensatory Reserve 
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Copyright information

© Springer-Verlag Italia 2005

Authors and Affiliations

  • Marek Czosnyka
    • 1
  • Zofia H. Czosnyka
    • 2
  • Peter C. Whitfield
    • 2
  • John D. Pickard
    • 1
  1. 1.NeurosurgeryAddenbrookes HospitalCambridgeUK
  2. 2.South West Neurosurgical UnitDarriford HospitalPlymouthUK

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