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Monounsaturated Fatty Acids and Neuroprotection. The Results of a Study of Cognitive Decline in Old Age. Is There a Case for this Treatment in Multiple Sclerosis?

  • A. Capurso
  • F. Panza
  • V. Solfrizzi
  • C. Capurso
  • A. D’Introno
  • S. Capurso
  • A. M. Colacicco
Part of the Topics in Neuroscience book series (TOPNEURO)

Abstract

Different diagnostic criteria have been proposed to distinguish individuals with mild cognitive disorders associated with aging. One of the best established of these classifications is age-associated memory impairment (AAMI) [1], but it is generally non-progressive and is thus more likely to be a phenomenon of normal aging [2, 3]. The terms “age-related cognitive decline” (ARCD) and “aging-associated cognitive decline” have been proposed recently [4, 5] to indicate an objective decline in cognitive functioning associated with the aging process but within normal limits given the person’s age. Whether ARCD is an expression of a normal aging process, represents a distinct clinical entity, or is a continuum with dementia is still difficult to establish [2, 6]. Recent results from longitudinal studies suggest that the subgroup at high risk for developing dementia may be identified by using a more-detailed procedure for the assessment of cognitive decline than those listed in the AAMI criteria. A high incidence (45%) of dementia was found in individuals aged >75 years who were diagnosed as having “minimal dementia” by the CAMDEX interview [7]. Furthermore, in another study 48% of patients with isolated memory loss of unknown cause developed dementia within 3.7 years [8].

Keywords

Multiple Sclerosis Cognitive Decline Multiple Sclerosis Patient Mediterranean Diet Macronutrient Intake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • A. Capurso
  • F. Panza
  • V. Solfrizzi
  • C. Capurso
  • A. D’Introno
  • S. Capurso
  • A. M. Colacicco

There are no affiliations available

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