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Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis pp 83–95Cite as

Imaging for Tissue Characterization in Multiple Sclerosis and Other White Matter Diseases

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Part of the book series: Topics in Neuroscience ((TOPNEURO))

Abstract

In white matter diseases (WMD), conventional magnetic resonance imaging (MRI) has proved to be sensitive for detecting lesions and their changes over time. However, conventional MRI is not able to characterize and quantify the tissue damage within and outside these lesions. Other quantitative MR techniques have the potential to overcome such limitation. Among these techniques, MR spectroscopy (MRS), magnetization transfer imaging (MTI), and diffusion-weighted imaging (DWI) have been most extensively applied to the assessment of WMD. The present review will summarize the major contributions of these three MR techniques to the understanding of the evolution of WMD, with a special focus on multiple sclerosis (MS). The application of MR techniques to the study of MS has indeed dramatically changed our understanding of how MS causes irreversible deficits and can serve as a useful model to be applied to other WMD.

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Authors
  1. M. Filippi
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  2. N. De Stefano
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Editors and Affiliations

  1. European Charcot Foundation, Nijmegen, The Netherlands

    Otto R. Hommes

  2. Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

    Giancarlo Comi

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Filippi, M., De Stefano, N. (2004). Imaging for Tissue Characterization in Multiple Sclerosis and Other White Matter Diseases. In: Hommes, O.R., Comi, G. (eds) Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2117-4_8

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  • DOI: https://doi.org/10.1007/978-88-470-2117-4_8

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2171-6

  • Online ISBN: 978-88-470-2117-4

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