Abstract
The term inflammation was first used as a gross description of the redness of the skin observed at sites of injury. Later it was discovered that the redness was the natural result of blood vessel physiology. Now we know that the blood vessels are only one of the many factors involved in inflammation, a process in which immune cells of various types and their molecular products interact with signal molecules produced by the injured tissue.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Florey HW (1970) General pathology, 4th ed Lloyd-Luke, London, pp 22–39
Cohen IR (2000) Tending Adam’s garden: evolving the cognative immune self. Academic Press, London
Schwartz M, Moalem G, Leibowitz-Amit, Cohen IR (1999) Innate and adaptive immune responses can be beneficial for CNS repair. Trends Neurosci 22:295–299
Schwartz M, Lazarov-Speigler O (1998) The role of immune system in central nervous system recovery: an evolutionary perspective. Curr Top Neurochem 1:123–132
Cohen IR (2000) Discrimination and dialogue in the immune system. Semin Immunol 12:215–219
Burnel M (1959) Self and not self. Cambridge University Press, Cambridge
Avarameas S (1991) Natural autoantibodies from “Horro Autotoxicus” to “Gnothi Seauton”. Immunol Today 12:154–159
Cohen IR (1992) The cognitive paradigm and the immunological homunculus. Immunol Today 13:490–494
Ben-Nun A, Wekerle H, Cohen IR (1981) The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 11:195–199
Moalem G et al (1999) Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5:49–55
Hauben E et al (2000) Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet 355:286–287
Schwartz M, Cohen IR (2000) Autoimmunity can benefit self-maintenance. Immunol Today 21:265–268
Yoles E et al (2001) Protective autoimmunity is a physiological response to CNS trauma. J Neurosci 21:3740–3748
Cohen IR, Young DB (1991) Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today 12:105–110
Cohen IR (1992) The cognitive principle challenges clonal selection. Immunol Today 13:441–444
Elias D, Tikochinski Y, Frankel G, Cohen IR (1999) Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide. Int Immunol 11:957–966
Waisman A et al (1996) Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med 2:899–905
Zang YC, Hong J, Tejada-Simon MV, Li S, Rivera VM, Killian JM, Zhang JZ (2000) Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis. Eur J Immunol 30:908–913
Zang YC, Hong J, Rivera VM, Killian J, Zhang JZ (2000) Preferential recognition of TCR hypervariable regions by human anti-idiotipic T cells induced by T cell vaccination. J Immunol 164:4011–4017
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer-Verlag Italia
About this chapter
Cite this chapter
Cohen, I.R. (2004). Autoimmune Inflammation and Multiple Sclerosis. In: Hommes, O.R., Comi, G. (eds) Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2117-4_6
Download citation
DOI: https://doi.org/10.1007/978-88-470-2117-4_6
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2171-6
Online ISBN: 978-88-470-2117-4
eBook Packages: Springer Book Archive