Inflammation, Demyelination, and Axonal Degeneration: Three Aspects of the Pathogenesis of Multiple Sclerosis Revealed by Campath-1H Treatment

  • A. J. Coles
  • M. G. Wing
  • P. Molyneux
  • A. Paolillo
  • C. M. Davie
  • G. Hale
  • D. Miller
  • H. Waldmann
  • A. Compston
Part of the Topics in Neuroscience book series (TOPNEURO)


It is hard to account for all the features of multiple sclerosis by episodes of demyelination and remyelination alone: the rapidity of recovery from a relapse, for instance, or the transition from relapsing-remitting disease to progressive accumulation of disability. Here, we report observation from the close study of a small number of patients treated with an experimental agent, Campath-1H, that cast some light on these issues.


Multiple Sclerosis Expand Disability Status Scale Axonal Degeneration Secondary Progressive Multiple Sclerosis Acute Optic Neuritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • A. J. Coles
  • M. G. Wing
  • P. Molyneux
  • A. Paolillo
  • C. M. Davie
  • G. Hale
  • D. Miller
  • H. Waldmann
  • A. Compston

There are no affiliations available

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