Anti-MOG Antibodies as Early Predictors for Conversion to Relapsing-Remitting Disease Course in Patients Suggestive of Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is the most common neurological disease in young adults, with the potential for subsequent chronic functional impairment and disability. MS exhibits not only heterogeneous clinical manifestations and disease courses but also heterogeneous neuropathological features. Recently, different neuropathological subtypes were defined, one characterized by features of antibody mediated immunopathogenesis [1]. A potential target antigen for autoreactive antibodies might be the central nervous system (CNS) specific myelin oligodendrocyte glycoprotein (MOG), which is exclusively localized on the surface of myelin sheaths and oligodendrocytes.