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Anti-MOG Antibodies as Early Predictors for Conversion to Relapsing-Remitting Disease Course in Patients Suggestive of Multiple Sclerosis

  • T. Berger
  • P. Rubner
  • R. Egg
  • E. Dilitz
  • D. Stadlbauer
  • F. Deisenhammer
  • C. Linington
  • M. Reindl
Part of the Topics in Neuroscience book series (TOPNEURO)

Abstract

Multiple sclerosis (MS) is the most common neurological disease in young adults, with the potential for subsequent chronic functional impairment and disability. MS exhibits not only heterogeneous clinical manifestations and disease courses but also heterogeneous neuropathological features. Recently, different neuropathological subtypes were defined, one characterized by features of antibody mediated immunopathogenesis [1]. A potential target antigen for autoreactive antibodies might be the central nervous system (CNS) specific myelin oligodendrocyte glycoprotein (MOG), which is exclusively localized on the surface of myelin sheaths and oligodendrocytes.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Myelin Basic Protein Optic Neuritis Myelin Oligodendrocyte Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Luccinetti CF, Brück W, Rodriguez M, Lassmann H (1996) Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol 6:259–274CrossRefGoogle Scholar
  2. 2.
    Reindl M, Linington C, Brehm U, Egg R, Dilitz E, Deisenhammer F, Berger T (1999) Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Brain 122:2047–2056PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • T. Berger
  • P. Rubner
  • R. Egg
  • E. Dilitz
  • D. Stadlbauer
  • F. Deisenhammer
  • C. Linington
  • M. Reindl

There are no affiliations available

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