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Antibody Mediated Demyelination

  • A. Van Der Goes
  • E. C. W. Breij
  • M. Kortekaas
  • K. Hoekstra
  • P. J. H. Jongen
  • C. D. Dijkstra
  • S. Amor
Part of the Topics in Neuroscience book series (TOPNEURO)

Abstract

Intrathecal oligoclonal IgG antibodies (Abs) are present in more than 90% of multiple sclerosis (MS) patients and the presence of such Abs serves as a laboratory marker supporting the diagnosis of this disease. The intrathecal IgG fractions contain Abs with many different specificities, including myelin-specific Abs. Reports on anti-myelin Abs in cerebrospinal (CSF) and sera are controversial [1-7]. Several reports describe the presence of anti-myelin Ab in serum and CSF, whereas others find anti-myelin Abs only in the CSF, and yet others report that anti-myelin Abs are absent in MS patients. However, B lymphocytes specific for, and plasma cells secreting Abs to myelin basic protein (MBP), myelin-associated glycoprotein (MAG), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP) are consistently detected in the central nervous system (CNS) of MS patients [8-11]. Such cells are even found in the CSF in the absence of anti-myelin Abs, suggesting that antibodies rapidly bind to target structures, such as the corresponding auto-antigens or to Fcreceptors, and therefore become undetectable [8, 9]. In organotypic, myelinated cultures of CNS tissue, sera of MS patients promoted myelin breakdown [12]. Similar results were obtained using rabbit anti-galactocerebroside (GalC) sera and anti-whole myelin sera [13, 14]. Genain et al. [15] identified auto-antibodies against MOG within acute MS lesions, where they were associated with damaged myelin membranes, and within macrophages ingesting myelin [15]. Lassmann et al. [16] described abundant deposition of immunoglobulins in a subclass of active MS.

Keywords

Multiple Sclerosis Myelin Basic Protein Experimental Allergic Encephalomyelitis Myelin Oligodendrocyte Glyco Central Nervous System Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2004

Authors and Affiliations

  • A. Van Der Goes
  • E. C. W. Breij
  • M. Kortekaas
  • K. Hoekstra
  • P. J. H. Jongen
  • C. D. Dijkstra
  • S. Amor

There are no affiliations available

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