Designing Future Clinical Trials for Acute Exacerbations of Chronic Bronchitis
To some extent, chronic bronchitis can be considered an orphan disease. In fact, most (if not all) of the drugs used in the stable phase of the disease have been initially developed for treating asthma. Similarly, most trials aimed at demonstrating the efficacy of antibiotics in acute exacerbations (AECB) have been modelled on pneumonia studies. Research in both asthma and pneumonia has been the inspiration of subsequent studies in chronic bronchitis in many cases. Furthermore, a specific approach to the disease which takes into account its unique characteristics has seldom been used by researchers.
KeywordsChronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Acute Exacerbation Chronic Bronchitis Respir Crit
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