Skip to main content

Antibiotics in the Treatment of Acute Exacerbations of Chronic Bronchitis: A Review of Controlled Clinical Trials

  • Chapter
  • 182 Accesses

Abstract

The term chronic bronchitis is clinically defined as the presence of excess mucus secretion, causing productive cough on most days for at least three months of the year for at least 2 consecutive years and when other causes of cough have been excluded [1]. When airway obstruction is also present, the term chronic obstructive pulmonary disease (COPD) is applied. The true epidemiological impact of COPD is unknown, but it is estimated that in the United States approximately 1 of 5 adult subjects are affected, and that this disease is the fourth leading cause of mortality [2,3].

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dantzker DR, Pingleton SK, Pierce JA, et al (1987) Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease and asthma. Am Rev Respir Dis 136:225–244

    Article  Google Scholar 

  2. -(1994) Statistical abstract of the United States: 1994, 114th edn. US Bureau of the Census, Washington DC

    Google Scholar 

  3. Woolcock AJ (1989) Epidemiology of chronic airways disease. Chest 96(Suppl 3): 302S–306S

    PubMed  CAS  Google Scholar 

  4. Murphy TF, Sethi S (1992) Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 146:1067–1083

    PubMed  CAS  Google Scholar 

  5. Fagon JY, Chastre J, Trouillet JL, et al (1990) Characterization of distal bronchial microflora during acute exacerbation of chronic bronchitis. Am Rev Respir Dis 142:1004–1008

    PubMed  CAS  Google Scholar 

  6. Ball P (1995) Epidemiology and treatment of chronic bronchitis and its exacerbations. Chest 108(Suppl):43S–52S

    Article  PubMed  CAS  Google Scholar 

  7. Gump DW, Philips CA, Forsyth BR, Mcintosh K, Lamborn KR, Stouch WH (1976) Role of infection in chronic bronchitis. Am Rev Respir Dis 113:465–474

    PubMed  CAS  Google Scholar 

  8. Gump DW, Christmas WA, Forsyth BR, Philips CA, Stouch WH (1973) Serum and secretory antibodies in patients with chronic bronchitis. Arch Intern Med 132:847–851

    Article  PubMed  CAS  Google Scholar 

  9. Kanner RE, Renzetti AD. Jr, Klauber MR, Smith CB, Golden CA (1979) Variables associated with spirometry in patients with obstructive lung disease. Am J Med 67:44–50

    Article  PubMed  CAS  Google Scholar 

  10. Cole P, Wilson R (1989) Host-microbial relationships in respiratory infection. Chest 95:217S–221S

    Article  Google Scholar 

  11. Wilson R (1995) Outcome predictors in bronchitis. Chest 198(Suppl):53S–57S

    Article  Google Scholar 

  12. Davies BL (1994) Critical review of microbiological data and methods in diagnosis of lower respiratory tract infections. Monaldi Arch Chest Dis 49:52–56

    PubMed  CAS  Google Scholar 

  13. Ball P, Wilson R (1994) The epidemiology and management of chronic bronchits, the Cinderella of chest diseases. In: Ball AP, Wilson R (eds) Epidemiology and management of chronic bronchitis. Cambridge Medical, Worthing, pp III–IX

    Google Scholar 

  14. Blasi F, Legnani D, Lombardo VM, Negretto GG, Magliano E, Pozzoli R, Chiodo F, Fasoli A, Allegra L (1993) Chlamydia pneumoniae infection in acute exacerbations of COPD. Eur Respir J 6:19–22

    PubMed  CAS  Google Scholar 

  15. The Working Party on Trials of Chemotherapy in Early Chronic Bronchitis of The Medical Research Council (1966) Value of chemoprophylaxis and chemotherapy in early chronic bronchitis. BMJ 1:317–322

    Google Scholar 

  16. Davis AL, Grobow EJ, Kaminski T, Tompsett R, McClement JH (1965) Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. II. Chemoprophylaxis with daily chloramphenicol. Am Rev Respir Dis 92:900–913

    PubMed  CAS  Google Scholar 

  17. Priedie RB, Datta N, Massey DG, Poole GW, Schneeweiss J, Stradling P (1960) A trial of continuous winter chemotherapy in chronic bronchitis. Lancet 2:723–727

    Article  Google Scholar 

  18. Francis RS, Spicer CC (1960) Chemotherapy in chronic bronchitis. Influence of daily penicillin and tetracycline on exacerbations and their costs. BMJ 1:297–303

    Article  PubMed  CAS  Google Scholar 

  19. Johnston RN, Lockart W, Smith DH, Cadman NK (1961) A trial of phenethicillin in chronic bronchitis. BMJ 2:985–986

    Article  PubMed  CAS  Google Scholar 

  20. Davis AL, Grobow EJ, Tompsett R, McClement JH (1961) Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. I. Chemoprophylaxis with intermittent tetracycline. Am J Med 31:365–381

    Article  PubMed  CAS  Google Scholar 

  21. Buchanan J, Buchanan WW, Melrose AG, McGuinness JB, Price AU (1958) Longterm prophylactic administration of tetracycline to chronic bronchitis. Lancet 2:719–722

    Article  PubMed  CAS  Google Scholar 

  22. Pines A (1967) Controlled trials of a sulphonamide given weekly to prevent exacerbations of chronic bronchitis. BMJ 3:202–204

    Article  PubMed  CAS  Google Scholar 

  23. Johnston RN, McNeill RS, Smith DH (1969) Five-year winter chemoprophylaxis for chronic bronchitis. BMJ 4:265–269

    Article  PubMed  CAS  Google Scholar 

  24. Murphy TF, Sethi S (1992) Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 146:1067–1083

    PubMed  CAS  Google Scholar 

  25. Elmes PC, Fletcher CM, Dutton AAC (1957) Prophylactic use of oxytetracycline for exacerbations of chronic bronchitis. BMJ 2:1272–1275

    Article  PubMed  CAS  Google Scholar 

  26. Berry DG, Fry J, Hindley CP (1960) Exacerbations of chronic bronchitis treatment with oxytetracycline. Lancet 1:137–139

    Article  PubMed  CAS  Google Scholar 

  27. Fear EC, Edwards G (1962) Antibiotic regimens in chronic bronchitis. Br J Dis Chest 56:153–162

    Article  PubMed  CAS  Google Scholar 

  28. Elmes PC, King TKC, Langlands JHM (1965) Value of ampicillin in the hospital treatment of exacerbations of chronic bronchitis. BMJ 2:904–908

    Article  PubMed  CAS  Google Scholar 

  29. Petersen ES, Esmann V, Honke P, Munkner C (1967) A controlled study of the effect of treatment on chronic bronchitis: an evaluation using pulmonary function tests. Acta Med Scand 182:293–305

    Article  PubMed  CAS  Google Scholar 

  30. Pines A, Raafat H, Greenfield JSB, Linsell WD, Solari ME (1972) Antibiotic regimens in moderately ill patients with purulent exacerbations of chronic bronchitis. Br J Dis Chest 66:107–115

    Article  PubMed  CAS  Google Scholar 

  31. Nicotra MB, Rivera M, Awe RJ (1982) Antibiotic therapy of acute exacerbations of chronic bronchitis. Ann Intern Med 97:18–21

    PubMed  CAS  Google Scholar 

  32. Anthonisen NR, Manfreda J, Warren CPW, Hershfield ES, Harding GKM, Nelson NA (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106:196–204

    PubMed  CAS  Google Scholar 

  33. Allegra L, Grassi C, Grossi E, Pozzi E, Blasi F, Frigerio D, Nastri A, Montanari C, Montanari M, Serra G (1991) Ruolo degli antibiotici nel trattamento delle riacutizzazioni della bronchite cronica: risultati di uno studio italiano multicentrico. Ital J Chest Dis 45:138–148

    Google Scholar 

  34. Jorgensen AF, Coolidge J, Pedersen PA (1992) Amoxicillin in treatment of acute uncomplicated exacerbations of chronic bronchitis. Scand J Prim Health Care 10:7–11

    Article  PubMed  CAS  Google Scholar 

  35. Saint S, Bent S, Vittinghoff E, Grady D (1995) Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA 273(12):957–960

    Article  PubMed  CAS  Google Scholar 

  36. Eller J, Ede A, Schaberg T, Niederman MS, Mauch H, Lode H (1998) Infective exacerbations of chronic bronchitis. Relation between bacteriologic etiology and lung function. Chest 113:1542–1548

    Article  PubMed  CAS  Google Scholar 

  37. Huchon G, Woodhead M (1998) Management of adult community-acquired lower respiratory tract infections. Eur Respir Rev 8:391–426

    Google Scholar 

  38. Dewan N, Destache CJ, O’Donohue WJ. Jr, Campbell JC, Angelillo VA (1994) Antibiotic choice and office visits for acute exacerbation of chronic bronchitis. Chest 106(Suppl):161S

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Italia

About this chapter

Cite this chapter

Blasi, F., Cosentini, R. (2000). Antibiotics in the Treatment of Acute Exacerbations of Chronic Bronchitis: A Review of Controlled Clinical Trials. In: Allegra, L., Blasi, F. (eds) Mechanisms and Management of COPD Exacerbations. Springer, Milano. https://doi.org/10.1007/978-88-470-2115-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2115-0_7

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0066-7

  • Online ISBN: 978-88-470-2115-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics