Abstract
The term chronic bronchitis is clinically defined as the presence of excess mucus secretion, causing productive cough on most days for at least three months of the year for at least 2 consecutive years and when other causes of cough have been excluded [1]. When airway obstruction is also present, the term chronic obstructive pulmonary disease (COPD) is applied. The true epidemiological impact of COPD is unknown, but it is estimated that in the United States approximately 1 of 5 adult subjects are affected, and that this disease is the fourth leading cause of mortality [2,3].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Dantzker DR, Pingleton SK, Pierce JA, et al (1987) Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease and asthma. Am Rev Respir Dis 136:225–244
-(1994) Statistical abstract of the United States: 1994, 114th edn. US Bureau of the Census, Washington DC
Woolcock AJ (1989) Epidemiology of chronic airways disease. Chest 96(Suppl 3): 302S–306S
Murphy TF, Sethi S (1992) Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 146:1067–1083
Fagon JY, Chastre J, Trouillet JL, et al (1990) Characterization of distal bronchial microflora during acute exacerbation of chronic bronchitis. Am Rev Respir Dis 142:1004–1008
Ball P (1995) Epidemiology and treatment of chronic bronchitis and its exacerbations. Chest 108(Suppl):43S–52S
Gump DW, Philips CA, Forsyth BR, Mcintosh K, Lamborn KR, Stouch WH (1976) Role of infection in chronic bronchitis. Am Rev Respir Dis 113:465–474
Gump DW, Christmas WA, Forsyth BR, Philips CA, Stouch WH (1973) Serum and secretory antibodies in patients with chronic bronchitis. Arch Intern Med 132:847–851
Kanner RE, Renzetti AD. Jr, Klauber MR, Smith CB, Golden CA (1979) Variables associated with spirometry in patients with obstructive lung disease. Am J Med 67:44–50
Cole P, Wilson R (1989) Host-microbial relationships in respiratory infection. Chest 95:217S–221S
Wilson R (1995) Outcome predictors in bronchitis. Chest 198(Suppl):53S–57S
Davies BL (1994) Critical review of microbiological data and methods in diagnosis of lower respiratory tract infections. Monaldi Arch Chest Dis 49:52–56
Ball P, Wilson R (1994) The epidemiology and management of chronic bronchits, the Cinderella of chest diseases. In: Ball AP, Wilson R (eds) Epidemiology and management of chronic bronchitis. Cambridge Medical, Worthing, pp III–IX
Blasi F, Legnani D, Lombardo VM, Negretto GG, Magliano E, Pozzoli R, Chiodo F, Fasoli A, Allegra L (1993) Chlamydia pneumoniae infection in acute exacerbations of COPD. Eur Respir J 6:19–22
The Working Party on Trials of Chemotherapy in Early Chronic Bronchitis of The Medical Research Council (1966) Value of chemoprophylaxis and chemotherapy in early chronic bronchitis. BMJ 1:317–322
Davis AL, Grobow EJ, Kaminski T, Tompsett R, McClement JH (1965) Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. II. Chemoprophylaxis with daily chloramphenicol. Am Rev Respir Dis 92:900–913
Priedie RB, Datta N, Massey DG, Poole GW, Schneeweiss J, Stradling P (1960) A trial of continuous winter chemotherapy in chronic bronchitis. Lancet 2:723–727
Francis RS, Spicer CC (1960) Chemotherapy in chronic bronchitis. Influence of daily penicillin and tetracycline on exacerbations and their costs. BMJ 1:297–303
Johnston RN, Lockart W, Smith DH, Cadman NK (1961) A trial of phenethicillin in chronic bronchitis. BMJ 2:985–986
Davis AL, Grobow EJ, Tompsett R, McClement JH (1961) Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. I. Chemoprophylaxis with intermittent tetracycline. Am J Med 31:365–381
Buchanan J, Buchanan WW, Melrose AG, McGuinness JB, Price AU (1958) Longterm prophylactic administration of tetracycline to chronic bronchitis. Lancet 2:719–722
Pines A (1967) Controlled trials of a sulphonamide given weekly to prevent exacerbations of chronic bronchitis. BMJ 3:202–204
Johnston RN, McNeill RS, Smith DH (1969) Five-year winter chemoprophylaxis for chronic bronchitis. BMJ 4:265–269
Murphy TF, Sethi S (1992) Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 146:1067–1083
Elmes PC, Fletcher CM, Dutton AAC (1957) Prophylactic use of oxytetracycline for exacerbations of chronic bronchitis. BMJ 2:1272–1275
Berry DG, Fry J, Hindley CP (1960) Exacerbations of chronic bronchitis treatment with oxytetracycline. Lancet 1:137–139
Fear EC, Edwards G (1962) Antibiotic regimens in chronic bronchitis. Br J Dis Chest 56:153–162
Elmes PC, King TKC, Langlands JHM (1965) Value of ampicillin in the hospital treatment of exacerbations of chronic bronchitis. BMJ 2:904–908
Petersen ES, Esmann V, Honke P, Munkner C (1967) A controlled study of the effect of treatment on chronic bronchitis: an evaluation using pulmonary function tests. Acta Med Scand 182:293–305
Pines A, Raafat H, Greenfield JSB, Linsell WD, Solari ME (1972) Antibiotic regimens in moderately ill patients with purulent exacerbations of chronic bronchitis. Br J Dis Chest 66:107–115
Nicotra MB, Rivera M, Awe RJ (1982) Antibiotic therapy of acute exacerbations of chronic bronchitis. Ann Intern Med 97:18–21
Anthonisen NR, Manfreda J, Warren CPW, Hershfield ES, Harding GKM, Nelson NA (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106:196–204
Allegra L, Grassi C, Grossi E, Pozzi E, Blasi F, Frigerio D, Nastri A, Montanari C, Montanari M, Serra G (1991) Ruolo degli antibiotici nel trattamento delle riacutizzazioni della bronchite cronica: risultati di uno studio italiano multicentrico. Ital J Chest Dis 45:138–148
Jorgensen AF, Coolidge J, Pedersen PA (1992) Amoxicillin in treatment of acute uncomplicated exacerbations of chronic bronchitis. Scand J Prim Health Care 10:7–11
Saint S, Bent S, Vittinghoff E, Grady D (1995) Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA 273(12):957–960
Eller J, Ede A, Schaberg T, Niederman MS, Mauch H, Lode H (1998) Infective exacerbations of chronic bronchitis. Relation between bacteriologic etiology and lung function. Chest 113:1542–1548
Huchon G, Woodhead M (1998) Management of adult community-acquired lower respiratory tract infections. Eur Respir Rev 8:391–426
Dewan N, Destache CJ, O’Donohue WJ. Jr, Campbell JC, Angelillo VA (1994) Antibiotic choice and office visits for acute exacerbation of chronic bronchitis. Chest 106(Suppl):161S
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag Italia
About this chapter
Cite this chapter
Blasi, F., Cosentini, R. (2000). Antibiotics in the Treatment of Acute Exacerbations of Chronic Bronchitis: A Review of Controlled Clinical Trials. In: Allegra, L., Blasi, F. (eds) Mechanisms and Management of COPD Exacerbations. Springer, Milano. https://doi.org/10.1007/978-88-470-2115-0_7
Download citation
DOI: https://doi.org/10.1007/978-88-470-2115-0_7
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0066-7
Online ISBN: 978-88-470-2115-0
eBook Packages: Springer Book Archive