Skip to main content

Abstract

Since the 1950s numerous consensus statements have been issued in the attempt to reach rational definitions and uniform terminology of diseases involving the lower airways [1-7]. These definitions represent a mixture of clinical, pathological and functional descriptions. The terms “chronic bronchitis” and “emphysema” date further back in time and are widely accepted. By the 1820s emphysema had been well defined, clearly described, and recognised to be common. The diagnosis of chronic bronchitis was first applied in 1805 to patients with chronic cough, breathlessness, and recurrent exacerbations during winter months. Conversely, a variety of definitions have been put forward to incorporate the concept of obstruction to airflow and chronic sputum production. Among these,“chronic obstructive pulmonary disease” (COPD) is certainly the most widely accepted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ciba Guest Symposium (1959) Terminology, definitions, and classification of chronic pulmonary emphysema and related conditions. Thorax 14:286–299

    Article  Google Scholar 

  2. American Thoracic Society (1962) Statement by the Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases: Definitions and classification of chronic bronchitis, asthma, and pulmonary emphysema. Am Rev Respir Dis 85:762–768

    Google Scholar 

  3. Fletcher CM, Pride NB (1984) Editorial: Definitions of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 years on from the CIBA symposium. Thorax 39:81

    Article  PubMed  CAS  Google Scholar 

  4. Canadian Thoracic Society Workshop Group (1992) Guidelines for the assessment and management of chronic obstructive pulmonary disease. Can Med Assoc J 147:420–424

    Google Scholar 

  5. Siafakas NM, Vermeire P, Pride NB, et al, on behalf of the Task Force (1995) ERS Consensus Statement. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). Eur Respir J 8:1393–1420

    Google Scholar 

  6. American Thoracic Society (1995) Standards for the diagnosis and care of patients with chronic obstructive pulmonary diseases. Am J Respir Crit Care Med 152:878–883

    Google Scholar 

  7. The COPD Guidelines Group of the Standards of Care Committee of the BTS (1997) BTS guidelines for the management of chronic obstructive pulmonary disease. Thorax 52:S1–S28

    Google Scholar 

  8. Dow L, Coggon D, Osmond C, Holgate ST (1991) A population survey of respiratory symptoms in the elderly. Eur Respir J 4:267–272

    PubMed  CAS  Google Scholar 

  9. Boezen M, Schouten JP, Postma DS, Rijcken B (1995) The relation between respiratory symptoms, pulmonary function and peak flow variability in adults. Thorax 50:121–126

    Article  PubMed  CAS  Google Scholar 

  10. Singh GK, Matthews TJ, Clarke SC, et al. (1994) Annual summary of births, marriages, divorces, and deaths: United States 1994. National Center for Health Statistics, Hyattsville (Monthly vital statistics report, vol. 43, n. 13)

    Google Scholar 

  11. -(1994) Morbidity and mortality chartbook on cardiovascular, lung, and blood diseases. National Heart, Lung and Blood Institute, Bethesda

    Google Scholar 

  12. -(1998) Strategies in preserving lung health and preventing COPD and associated diseases. The National Lung Health Education Program (NLHEP). Chest 113(2):123S–163S

    Google Scholar 

  13. Oswald NC (1959) Chronic bronchitis and emphysema: A symposium II. Clinical aspects of chronic bronchitis. Br J Radiol 32:289–292

    Article  PubMed  CAS  Google Scholar 

  14. Fletcher CM (1959) Chronic bronchitis. Its prevalence, nature, and pathogenesis. Am Rev Respir Dis 80:483

    PubMed  CAS  Google Scholar 

  15. World Health Organization (1975) International classification of disease, 9th revision. WHO, Geneva

    Google Scholar 

  16. Benson V, Marano MA (1994) Current estimates from the National Health Interview Survey, 1993. National Center for Health Statistics, Washington (Vital and health statistics 10(190), DHHS publication no. (PHS) 95–1518)

    Google Scholar 

  17. Wilder C (1973) Prevalence of selected chronic respiratory conditions: United States, 1970. National Center for Health Statistics, Washington (Vital and health statistics 10(84), DHEW publication no. (HRA) 95–1518)

    Google Scholar 

  18. Tirimana P.R, van Schayack CP, den Otter JJ, et al. (1996) Prevalence of asthma and COPD in 1992: has it changed since 1977? Br J Gen Pract 46:277–281

    Google Scholar 

  19. Collins JC (1993) Prevalence of selected chronic respiratory conditions: United States, 1986–1988. National Center for Health Statistics, Washington (Vital and health statistics 10(182), DHHS publication no. (PHS) 93–1510 415

    Google Scholar 

  20. Feinleib M, Rosenberg HM, Cillons JG, et al. (1989) Trends in COPD morbidity and mortality in the United States. Am Rev Respir Dis 140:S9–S18

    PubMed  CAS  Google Scholar 

  21. Lung and Asthma Information Agency (1992) Trends in asthma mortality in the elderly. 92:1

    Google Scholar 

  22. Thorn TJ (1989) International comparisons in COPD mortality. Am Rev Respir Dis 140(Suppl):S27–S34

    Google Scholar 

  23. Higgins MW, Thorn TJ (1989) Incidence, prevalence and mortality: Intra-and intercountry differences. In: Hensley MJ, Sauders NA (eds) Clinical epidemiology of chronic obstructive pulmonary disease. Marcel Dekker, New York, pp 23–43

    Google Scholar 

  24. Davis RM, Novotny TE (1989) Changes in risk factors. The epidemiology of cigarette smoking and its impact on chronic obstructive pulmonary disease. Am Rev Respir Dis 140(Suppl):S82–S84

    Article  PubMed  CAS  Google Scholar 

  25. Higgins MW (1989) Chronic airways disease in the United States. Trends and determinants. Chest 96(Suppl):328S–334S

    PubMed  CAS  Google Scholar 

  26. Miller GJ (1974) Cigarette smoking and irreversible airways obstruction in the West Indies. Thorax 29:495–504

    Article  PubMed  CAS  Google Scholar 

  27. Cullen KJ, Stenhouse NS, Welborn TA, et al. (1968) Chronic respiratory disease in a rural community. Lancet 2:657–660

    Article  PubMed  CAS  Google Scholar 

  28. Lange P, Groth S, Nynoe J, et al. (1990) Decline of the lung function related to the type of tobacco smoked and inhalation. Thorax 45:22–26

    Article  PubMed  CAS  Google Scholar 

  29. Beck GJ, Doyle CA, Schacter EN (1981) Smoking and lung function. Am Rev Respir Dis 123:149–155

    PubMed  CAS  Google Scholar 

  30. Harris JE (1983) Cigarette smoking among successive birth cohorts of men and women in the United States during 1900–1980. J Natl Cancer Inst 71:473–479

    PubMed  CAS  Google Scholar 

  31. United States Public Health Service (1964) Smoking and health. Report of the Advisory Committee of the Surgeon General. U.S. Government Printing Office, Washington 44:277. (PHS publ. 1103)

    Google Scholar 

  32. United States Public Health Service (1964) The health consequences of smoking. Chronic obstructive lung disease: A report of the Advisory Committee of the Surgeon General. U.S. Government Printing Office, Rockville, 9, 75–118, 185–260, 348–352,361–412. (DHHS publ. (PHS) 84–50205)

    Google Scholar 

  33. Fletcher C, Peto R, Tinker C, Speizer FE (1976) The natural history of chronic bronchitis and emphysema. Oxford University, Oxford

    Google Scholar 

  34. Peto R, Speizer FE, Cochrane AL, et al. (1983) The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Am Rev Respir Dis 128:491–500

    PubMed  CAS  Google Scholar 

  35. Xu X, Weiss ST, Rijcken B, Schouten JP (1994) Smoking, changes in smoking habits, and rate of decline in FEVI: new insight into gender differences. Eur Respir J 7:1056–1061

    Article  PubMed  CAS  Google Scholar 

  36. Burchfield CM, Marcus EB, Curb JD, et al. (1995) Effects of smoking and smoking cessation on longitudinal decline in pulmonary function. Am J Respir Crit Care Med 151:1778–1785

    Google Scholar 

  37. Doll R, Peto R, Wheatley K, et al. (1994) Mortality in relation to smoking: 40 years’ observation on male British doctors. BMJ 309:901–911

    Article  PubMed  CAS  Google Scholar 

  38. Leuenberger P, Schwartz J, Ackermannliebrich U, et al. (1994) Passive smoking exposure in adults and chronic respiratory symptoms (SALPALDIA study). Am J Respir Crit Care Med 150:1222–1228

    PubMed  CAS  Google Scholar 

  39. Jarvis MJ, Russell MAH, Feyerabend C. (1983) Absorption of nicotine and carbon monoxide from passive smoking under natural conditions of exposure. Thorax 31:829–833

    Article  Google Scholar 

  40. Burchfiel CM, Higgins MW, Keller JB, et al. (1986) Passive smoking in childhood. Respiratory conditions and pulmonary function in Tecumseh, Michigan. Am Rev Respir Dis 133:966–973

    PubMed  CAS  Google Scholar 

  41. United States Public Health Service (1979) Smoking and health. A report of the Surgeon General. U.S. Government Printing Office, Washington 4:1–7; 5:1–74; 6:1–52 8:1–93. (DHEW publ. PHS 79-50066)

    Google Scholar 

  42. Logan WPD (1953) Mortality in London fog incident. Lancet 1:336–338

    Article  PubMed  CAS  Google Scholar 

  43. Shrenk HH, Heimann H, Clayton GD, et al. (1949) Air pollution in Donora, PA: Epidemiology of the unusual smog episode of October 1948. Preliminary report. Public Health Service, Washington (Public health bulletin 306)

    Google Scholar 

  44. Bascom R, Bromberg PA, Costa DA, et al. (1996) Health effects of outdoor air pollution. Am J Crit Care Med 153:3–50

    Google Scholar 

  45. Lebowitz MD (1996) Epidemiological studies of the respiratory effects of air pollution. Eur Respir J 9:1029–1054

    Article  PubMed  CAS  Google Scholar 

  46. Morgan WKC (1986) On dust, disability and death (editorial). Am Rev Respir Dis 134:639

    PubMed  CAS  Google Scholar 

  47. Zapletal A, Jech J, Paul T, et al. (1973) Pulmonary function studies in children living in an air-polluted area. Am Rev Respir Dis 107:400–409

    PubMed  CAS  Google Scholar 

  48. Tashkin DP, Detels R, Simmons M, et al. (1994) The UCLA population studies of chronic respiratory disease. 6. Impact of air pollution and smoking on annual change in forced expiratory volume in one second. Am J Crit Care Med 149:1209–1217

    CAS  Google Scholar 

  49. Attfield MD, Hodous TK (1992) Pulmonary function of US coal miners related to dust exposure estimates. Am Rev Respir Dis 145:605–609

    PubMed  CAS  Google Scholar 

  50. Hnizdo E (1992) Loss of lung function associated with exposure to silica dust and with smoking and its relation to disability and mortality in South Africa gold miners. Br J Ind Med 49:472–494

    PubMed  CAS  Google Scholar 

  51. Davidson AG, Newman Taylor AJ, Darbyshire J, et al. (1988) Cadmium fume inhalation and emphysema. Lancet 1:663–667

    Article  Google Scholar 

  52. Smid T, Heederik D, Houba R, Quanjer PH (1992) Dust and endotoxin-related respiratory effects in the animal feed industry. Am Rev Respir Dis 146:1474–1479

    PubMed  CAS  Google Scholar 

  53. Nejjari C, Tessier JF, Dartigues JF, et al. (1993) The relationship between dyspnoea and main lifetime occupation in the elderly. Int J Epidemiol 22:848–854

    Article  PubMed  CAS  Google Scholar 

  54. Bakke PS, Baste V, Hanoa R, Gulsvik A (1991) Prevalence of obstructive lung disease in a general population: relation to occupational title and exposure to some airborne agents. Thorax 6:863–870

    Article  Google Scholar 

  55. Becklake MR (1989) Occupational exposures: evidence for a causal association with chronic obstructive pulmonary disease. Am Rev Respir Dis 140(Suppl):S85–S91

    PubMed  CAS  Google Scholar 

  56. Korn RJ, Dockery DW, Speizer FE, et al. (1987) Occupational exposures and chronic respiratory symptoms. A population-base study. Am Rev Respir Dis 136:298–304

    Article  PubMed  CAS  Google Scholar 

  57. Wilson R (1998) The role of infection in COPD. Chest 113:242S–248S

    Article  PubMed  CAS  Google Scholar 

  58. Murphy TF, Sethi S (1992) Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 146:1067–1083

    Google Scholar 

  59. Fletcher C, Peto R (1977) The natural history of chronic airflow obstruction. Br Med J 1:1645–1648

    Article  PubMed  CAS  Google Scholar 

  60. Kanner RE, Renzetti AD Jr, Klauber MR, Smith CB, Golden CA (1979) Variables associated with changes in spirometry in patients with obstructive lung diseases. Am J Med 67:44–50

    Article  PubMed  CAS  Google Scholar 

  61. Bascom R (1991) Differential susceptibility to tobacco smoke: possible mechanisms. Pharmacogenetics 1:102–106

    Article  PubMed  CAS  Google Scholar 

  62. Madison R, Zelman R, Mittman C (1980) Inherited risk factors for chronic lung disease. Chest 77(2 Suppl):255–257

    PubMed  CAS  Google Scholar 

  63. Tager IB, Rosner B, Tishler PV, Speizer F.E, Kass E.H. (1976) Household aggregation of pulmonary function and chronic bronchitis. Am Rev Respir Dis 114:485–492

    PubMed  CAS  Google Scholar 

  64. Devor EJ, Crawford MH (1984) Family resemblance for normal pulmonary function. Ann Human Biol 11:439–448

    Article  CAS  Google Scholar 

  65. Redline S, Tishler PV, Rosner B, et al. (1989) Genotypic and phenotypic similarities in pulmonary function among family members of adult monozygotic and dizygotic twins. Am J Epidemiol 129:827–836

    PubMed  CAS  Google Scholar 

  66. Webster PM, Lorimer EG, Man SFP, Woolf CR, Zamel N. (1979) Pulmonary function in identical twins: comparison of nonsmokers and smokers. Am Rev Respir Dis 119:223–228

    PubMed  CAS  Google Scholar 

  67. Hankins D, Drage C, Zamel N, Kronenberg R (1982) Pulmonary function in identical twins raised apart. Am Rev Respir Dis 125:119–121

    PubMed  CAS  Google Scholar 

  68. Soubrier F, Lathrop GM. (1995) The genetic basis of hypertension. Curr Opin Nephrol Hyperten 4:177–181

    Article  CAS  Google Scholar 

  69. Davies JL, Kawaguchi Y, Bennett ST, et al. (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371:130–136

    Article  PubMed  CAS  Google Scholar 

  70. Cox DW, Johnson AM, Fagerhol MK (1980) Report of nomenclature meeting for alpha1-antitrypsin. Hum Genet 53:429–433

    Article  PubMed  CAS  Google Scholar 

  71. Janus AD, Philips NT, Carrell RW (1985) Smoking, lung function and alpha1-antitrypsin deficiency. Lancet 1(8421): 152–154

    Article  PubMed  CAS  Google Scholar 

  72. Brantley ML, Paul LD, Miller BH, et al. (1988) Clinical features and history of the destructive lung disease associated with alphal-antitrypsin deficiency of adults with respiratory symptoms. Am Rev Respir Dis 138:327–336

    Google Scholar 

  73. Klayton R, Fallat R, Cohen AB (1975) Determinants of chronic obstructive pulmonary disease in patients with intermediate levels of alphal-antitrypsin. Am Rev Respir Dis 112:71–75

    PubMed  CAS  Google Scholar 

  74. Tattersall SF, Pereira RP, Hunter D, et al. (1979) Lung distensibility and airway function in intermediate alphal-antitrypsin deficiency. Thorax 34:637–646

    Article  PubMed  CAS  Google Scholar 

  75. Tärjan E, Magyar P, Vaczi Z, et al. (1994) Longitudinal lung function study in heterozygous PiMZ phenotype subjects. Eur Respir J 7:2199–2204

    Article  PubMed  Google Scholar 

  76. Morse JO, Ldebowitz MD, Knudson RJ, Burrows B (1977) Relation of protease inhibitor phenotypes to obstructive lung diseases in a community. N Engl J Med 296:1190–1194

    Article  PubMed  CAS  Google Scholar 

  77. Bruce RM, Cohen BH, Diamond EL, et al. (1984) Collaborative study to assess the risk of lung disease in Pi Mz phenotype subjects. Am Rev Respir Dis 130:386–390

    PubMed  CAS  Google Scholar 

  78. Poller W, Faber J-B, Scholz S, et al. (1992) Mis-sense mutation of αl-antichymotrypsin gene associated with chronic lung disease. Lancet 339:1538

    Article  PubMed  CAS  Google Scholar 

  79. Poller W, Faber J-B, Weidinger S, et al. (1993) A leucine-to-proline substitution causes a defective α1-antichymotrypsin allele associated with familial obstructive lung disease. Genomics 17:740–743

    Article  PubMed  CAS  Google Scholar 

  80. Kerem B-S, Rommens JM, Buchanan JA, et al. (1989) Identification of the cystic fibrosis gene: genetic analysis. Science 245:1073–1080

    Article  PubMed  CAS  Google Scholar 

  81. Gervais R, Lafitte J-J, Dumur V, et al. (1993) Sweat chloride and ΔF508 mutation in chronic bronchitis or bronchiectasis. Lancet 342:997

    Article  PubMed  CAS  Google Scholar 

  82. Pignatti PF, Bombieri C, Marigo C, et al. (1995) Increased incidence of cystic fibrosis gene mutations in adults with disseminated bronchiectasis. Hum Mol Genet 4:635–636

    Article  PubMed  CAS  Google Scholar 

  83. Gasparini P, Savoia A, Luisetti M, et al. (1990) The cystic fibrosis gene is not likely to be involved in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2:297–299

    PubMed  CAS  Google Scholar 

  84. Artlich A, Boysen A, Bunge S, et al. (1995) Common CFTR mutations are not likely to predispose to chronic bronchitis in Northern Germany. Hum Genet 95:226–228

    Article  PubMed  CAS  Google Scholar 

  85. Kew RR, Webster RO. (1988) Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg. J Clin Invest 82:364–369

    Article  PubMed  CAS  Google Scholar 

  86. Yamamoto N, Homma S (1991) Vitamin D-binding protein (group-specific component) is a precursor for the macrophage-activating signal factor for lysophosphatidylcholine-treated lymphocytes. Proc Natl Acad Sci USA 88:8539–8543

    Article  PubMed  CAS  Google Scholar 

  87. Home SL, Cockcroft DW, Dosman JA. (1990) Possible protective effect against chronic obstructive airways disease by the GC 2 allele. Hum Hered 40:173–176

    Article  Google Scholar 

  88. Kaufmann F, Kleisbauer J-P, Cambon-de-Mouzon A, et al. (1983) Genetic markers in chronic airflow limitation: a genetic epidemiology study. Am Rev Respir Dis 127:263–269

    Google Scholar 

  89. Haines AP, Imeson JD, Meade TW. (1982) ABH secretor status and pulmonary function. Am J Epidemiol 115:367–370

    PubMed  CAS  Google Scholar 

  90. Home SL, Cockroft DW, Lovegrove A, Dosman JA. (1985) ABO, Lewis and secretor status and relative incidence of airflow obstruction. Dis Markers 3:55–62

    Google Scholar 

  91. O’Keefe S, Gzel A, Drury R, et al. (1991) Immunoglobulin G subclasses and spirometry in patients with chronic obstructive pulmonary disease. Eur Respir J 4:932–938

    Google Scholar 

  92. Webb Dr, Condemi JJ (1974) Selective immunoglobulin A deficiency and chronic obstructive lung disease. Ann Intern Med 80:618–621

    PubMed  CAS  Google Scholar 

  93. Poller W, Barth J, Voss B (1989) Detection of an alteration of the alpha2-microglobulin gene in a patient with chronic lung disease and serum alpha2-microglobulin deficiency. Hum Genet 83:93–96

    Article  PubMed  CAS  Google Scholar 

  94. Cantlay AM, Lamb D, Gillooly M, et al. (1995) Association between CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer. J Clin Pathol Mol Pathol 48:M210–214

    Article  CAS  Google Scholar 

  95. Peno-Green L, Crapo JD, Folz RJ (1995) Characterisation of human serum extracellular superoxide dismutase variants in normal and lung disease individuals. Am J Respir Crit Care Med 151;A167

    Google Scholar 

  96. Abe T, Kobayashi N, Yoshimura K, et al. (1991) Expression of the secretory leukoprotease inhibitor gene in epithelial cells. J Clin Invest 87:2207–2215

    Article  PubMed  CAS  Google Scholar 

  97. Lüdecke B, Poller W, Olek K, Bartholome K (1993) Sequence variant of the human cathepsin G gene. Hum Genet 91:83–84

    Article  PubMed  Google Scholar 

  98. Sandford AJ, Weir TD, Paré PD (1997) Genetic risk factors for chronic obstructive pulmonary disease. Eur Respir J 10:1380–1391

    Article  PubMed  CAS  Google Scholar 

  99. Burrows B, Cline MG, Knudson RJ, et al. (1983) A descriptive analysis of the growth and decline of the FVC and FEVI. Chest 83:717–724

    Article  PubMed  CAS  Google Scholar 

  100. Sherill DL, Camilli A, Lebowitz MD (1989) On the temporal relationship between lung function and somatic growth. Am Rev Respir Dis 140:638–644

    Google Scholar 

  101. Dockery DW, Berkey CS, Ware JH, et al. (1983) Distribution of forced vital capacity and forced expiratory volume in one second in children 6–11 years of age. Am Rev Respir Dis 128:405–412

    PubMed  CAS  Google Scholar 

  102. Rennard SI (1998) COPD: Overview of definitions, epidemiology, and factors influencing its development. Chest 113:235S–241S

    Article  PubMed  CAS  Google Scholar 

  103. Annesi I, Kaufmann F (1986) Is respiratory mucus hypersecretion really an innocent disorder? Am Rev Respir Dis 134:688–693

    PubMed  CAS  Google Scholar 

  104. Vestbo J, Prescott E, Lange P (1996) Association of chronic mucus hypersecretion with FEVI decline and chronic obstructive pulmonary disease morbidity. Am J Crit Care Med 153:1530–1535

    CAS  Google Scholar 

  105. Van der Lende R, Visser BF, Wever-Hess J, et al. (1973) Distribution of histamine threshold values in a random population. Reveu de l’Institut d’Hygiene des Mines Hasselt (Belgium) 28:186–190

    Google Scholar 

  106. Weiss ST, Speizer FE (1984) Increased level of airways responsiveness as a risk factor for development of chronic obstructive lung disease: what are the issues? Chest 86:3

    Article  PubMed  CAS  Google Scholar 

  107. Sparrow D, O’Connor G, Colton TH, et al. (1987) The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. Am Rev Respir Dis 135:1255–1260

    PubMed  CAS  Google Scholar 

  108. Rijcken B, Schouten JP, Weiss ST, et al. (1988) The relationship between airway responsiveness to histamine and pulmonary function level in a random population sample. Am Rev Respir Dis 137:826–832

    PubMed  CAS  Google Scholar 

  109. Mensinga TT, Schouten JP, Rijcken B, et al. (1990) The relationship of eosinophilia and positive skin test reactivity to respiratory symptom prevalence in a community-based population study. J Allergy Clin Immunol 86:99–107

    Article  PubMed  CAS  Google Scholar 

  110. Villar MT, Dow L, Coggon D, et al. (1995) The influence of increased bronchial responsiveness, atopy and serum IgE on decline in FEV1; a longitudinal study in the elderly. Am J Respir Crit Care Med 151:656–662

    PubMed  Google Scholar 

  111. Rijcken B, Schouten JP, Xu X, et al. (1995) Airway hyperresponsiveness to histamine is associated with accelerated decline of FEV1. Am J Respir Crit Care Med 151:1377–1382

    PubMed  CAS  Google Scholar 

  112. Pride NB (1988) Bronchial hyperactivity in smokers. Eur Respir J 1:485–487

    PubMed  CAS  Google Scholar 

  113. Burrows B, Martinez FD (1989) Bronchial responsiveness, atopy, smoking and chronic obstructive pulmonary disease (editorial). Am Rev Respir Dis 140:1515–1517

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Italia

About this chapter

Cite this chapter

Allegra, L., Tarsia, P. (2000). COPD Epidemiology and Natural History. In: Allegra, L., Blasi, F. (eds) Mechanisms and Management of COPD Exacerbations. Springer, Milano. https://doi.org/10.1007/978-88-470-2115-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2115-0_2

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0066-7

  • Online ISBN: 978-88-470-2115-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics