Perspectives and Perceptions on the Management of Acute Exacerbations of COPD

  • L. Allegra
  • F. Blasi


Chronic obstructive pulmonary disease (COPD) is present in 20% of the population in the United States [1]. The development of the disease involves multiple risk factors including genetic predisposition, maternal smoking, nutrition, allergens, active and passive smoking, infection, air pollution, etc. In the past decades two major theories have been put forward to explain the pathogenesis of chronic bronchitis. The Dutch and the British hypotheses have generally been considered competing theories, the first underscoring the importance of hyperreactivity, the latter the role of infection [2, 3] . However, as suggested by Rennard, the underlying process is an upsetting of the tissue damage/tissue repair balance that initiates inflammatory derangement directly leading to airway remodelling and airflow obstruction [4].


Chronic Obstructive Pulmonary Disease Acute Exacerbation Chronic Bronchitis Maternal Smoking Obstructive Lung Disease 
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Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • L. Allegra
    • 1
  • F. Blasi
    • 1
  1. 1.Institute of Respiratory DiseasesUniversity of Milan, IRCCS Ospedale MaggioreMilanItaly

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