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The Hemoglobin Polymorphism in Sardinian Goats: Nucleotide Sequence and Frequency of ßA, ßD, ßD-Malta, and ßE Globin Genes

  • M. Pirastru
  • M. Palici Di Suni
  • G. M. Vacca
  • P. Franceschi
  • B. Masala
  • L. Manca

Abstract

As in most vertebrates, the goat α-globin gene locus is duplicated though producing Iα and IIα globin chains that differ in three amino acid residues [[1]–[3]]. As the result of an unusual evolutionary history, however, a goat (β-globin gene cluster consists of 12 genes organized as a triplicated four-gene set located on chromosome 7: 5’-εIII-ψβXCIIIIV-ψβYAVVI-ψβZF-3’[[4]-[6]]. The βA-globin gene is expressed in adult animals, whereas βF and βC genes are expressed in the fetus and in juveniles up to 6 months of age, respectively [[7]]. During the first year of postnatal life, the synthesis of pre-adult βC-globin is supplanted by the synthesis of adult βA. The βC→βA switch is reversible and the reactivation of the βC synthesis, at the expense of βA, can be induced by anemia, hypoxia, or the administration of erythropoietin [[1],[8]]. Due to this unusual feature, which is also common in sheep hemoglobin (Hb) type A and in Sardinian mouflon [[5], [7], [9], [10]], the organization of globin genes, the nucleotide sequence, and the evolution of goat and sheep globin genes have been extensively studied [[1]–[2], [11]–[13]].

Keywords

Globin Gene Globin Chain Chain Variant Globin Locus Globin Gene Cluster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • M. Pirastru
    • 1
  • M. Palici Di Suni
    • 1
  • G. M. Vacca
    • 2
  • P. Franceschi
    • 3
  • B. Masala
    • 1
  • L. Manca
    • 1
  1. 1.Dept. of Phisiological, Biochemical and Cell SciencesUniversity of SassariSassariItaly
  2. 2.Dept. of Animal BiologyUniversity of SassariSassariItaly
  3. 3.CEVARENUniversity of CorteCorteFrance

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