Correlations between Magnetic Resonance Spectroscopy and Other Magnetic Resonance Parameters in Multiple Sclerosis

  • M. Rovaris
  • M. Filippi
Part of the Topics in Neuroscience book series (TOPNEURO)


Magnetic resonance spectroscopy (MRS) can complement conventional magnetic resonance (MR) imaging in the assessment of patients with multiple sclerosis (MS), by defining simultaneously several chemical correlates of the pathological changes occuring within and outside T2-visible lesions [1,2].


Multiple Sclerosis Expand Disability Status Scale Multiple Sclerosis Lesion Magnetization Transfer Ratio RRMS Patient 
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  1. 1.
    Arnold DL, Wolinsky JS, Matthews PM, Falini A (1998) The use of magnetic resonance spectroscopy in the evaluation of the natural history of multiple sclerosis. J Neurol Neurosurg Psychiatry 64 [Suppl 1]: S94–S101PubMedGoogle Scholar
  2. 2.
    Arnold DL (1999) Magnetic resonance spectroscopy: imaging axonal damage in MS. J Neuroimmunol 98: 2–6PubMedCrossRefGoogle Scholar
  3. 3.
    Davie CA, Hawkins CP, Barker GJ et al (1994) Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 117: 49–58PubMedCrossRefGoogle Scholar
  4. 4.
    De Stefano N, Matthews PM, Antel JP et al (1996) Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 38: 901–909CrossRefGoogle Scholar
  5. 5.
    Narayana PA, Doyle TJ, Lai DJ, Wolinsky JS (1998) Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 43: 56–71PubMedCrossRefGoogle Scholar
  6. 6.
    Arnold DL, Matthews PM, Francis GS et al (1992) Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 31: 235–241PubMedCrossRefGoogle Scholar
  7. 7.
    De Stefano N, Matthews PM, Arnold DL (1995) Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 34: 721–727PubMedCrossRefGoogle Scholar
  8. 8.
    De Stefano N, Matthews PM, Fu LQ et al (1998) Axonal damage correlates with dis ability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain 121: 1469–1477PubMedCrossRefGoogle Scholar
  9. 9.
    Tourbah A, Stievenart JL, Gout O et al (1999) Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis. Neurology 53: 1091–1097PubMedCrossRefGoogle Scholar
  10. 10.
    Fu L, Matthews PM, De Stefano N et al (1998) Imaging axonal damage of normalappearing white matter in multiple sclerosis. Brain 121: 159–166CrossRefGoogle Scholar
  11. 11.
    Rovaris M, Filippi M (1999) Magnetic resonance techniques to monitor disease evolution and treatment trial outcomes in multiple sclerosis. Curr Opin Neurol 12: 337–344PubMedCrossRefGoogle Scholar
  12. 12.
    Rovaris M, Filippi M (2000) The value of new magnetic resonance techniques in multiple sclerosis. Curr Opin Neurol 13: 249–254PubMedCrossRefGoogle Scholar
  13. 13.
    van Walderveen MAA, Kamphorst W, Scheltens P et al (1998) Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 50: 1282–1288PubMedCrossRefGoogle Scholar
  14. 14.
    Filippi M, Grossman RI, Comi G (eds) (1999) Magnetization transfer in multiple sclerosis. Neurology 53: (Suppl 3)Google Scholar
  15. 15.
    Le Bihan D, Turner R, Pekar J, Moonen CTW (1991) Diffusion and perfusion imaging by gradient sensitization: design, strategy and significance. J Magn Reson Imaging 1:7–8PubMedCrossRefGoogle Scholar
  16. 16.
    Filippi M, Horsfield MA, Ader HJ et al (1998) Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. Ann Neurol 43: 499–506PubMedCrossRefGoogle Scholar
  17. 17.
    Filippi M, Grossman RI, Comi G (eds) (1999) Magnetic resonance techniques in clinical trials in multiple sclerosis. Springer, MilanGoogle Scholar
  18. 18.
    McDonald WI, Miller DH, Barnes D (1992) The pathological evolution of multiple sclerosis. Neuropathol Appl Neurobiol 18: 319–334PubMedCrossRefGoogle Scholar
  19. 19.
    Matthews PM, Pioro E, Narayanan S et al (1996) Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain 119: 715–722PubMedCrossRefGoogle Scholar
  20. 20.
    Sarchielli P, Presciutti O, Pelliccioli GP et al (1999) Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients. Brain 122: 513–521PubMedCrossRefGoogle Scholar
  21. 21.
    Arnold DL, Riess GT, Matthews PM et al (1994) Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Ann Neurol 36: 76–82PubMedCrossRefGoogle Scholar
  22. 22.
    De Stefano N, Matthews PM, Narayanan S et al (1997) Axonal dysfunction and disability in a relapse of multiple sclerosis: longitudinal study of a patient. Neurology 49: 1138–1141PubMedCrossRefGoogle Scholar
  23. 23.
    De Stefano N, Narayanan S, Matthews PM et al (1999) In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis. Brain 122: 1933–1939PubMedCrossRefGoogle Scholar
  24. 24.
    Sarchielli P, Presciutti O, Tarducci R et al (1998) 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-la: results of a preliminary study. J Neurol Neurosurg Psychiatry 64: 204–212PubMedCrossRefGoogle Scholar
  25. 25.
    van Walderveen MAA, Barkhof F, Hommes OR et al (1995) Correlating MRI and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short TR/short TE (Trweighted) spin-echo images. Neurology 45: 1684–1690PubMedCrossRefGoogle Scholar
  26. 26.
    Truyen L, van Waesberghe JHTM, van Walderveen MAA et al (1997) Accumulation of hypointense lesions (“black holes”) on Tl spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology 47: 1469–1476CrossRefGoogle Scholar
  27. 27.
    Jagust WJ, Noseworthy JH (2000) Brain atrophy as a surrogate marker in MS. Faster, simpler, better? Neurology 54: 782–783PubMedCrossRefGoogle Scholar
  28. 28.
    Ge Y, Grossman RI, Udupa JK et al (2000) Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal quantitative analysis. Radiology 214: 665–670PubMedGoogle Scholar
  29. 29.
    Simon HJ, Jacobs LD, Campion MK et al (1999) A longitudinal study of brain atrophy in relapsing multiple sclerosis. Neurology 53: 139–148PubMedCrossRefGoogle Scholar
  30. 30.
    Brex PA, Parker GJM, Leary SM et al (2000) Lesion heterogeneity in multiple sclerosis: a study of the relations between appearance on T1 weighted images, T1 relaxation times, and metabolite concentrations. J Neurol Neurosurg Psychiatry 68: 627–632PubMedCrossRefGoogle Scholar
  31. 31.
    van Walderveen MAA, Barkhof F, Pouwels PJW et al (1999) Neuronal damage in Tlhypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Ann Neurol 46: 79–87PubMedCrossRefGoogle Scholar
  32. 32.
    van Waesberghe JH, Kamphorst W, DeGroot CJ et al (1999) Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability. Ann Neurol 46: 747–754PubMedCrossRefGoogle Scholar
  33. 33.
    Coles AJ, Wing MG, Molyneux P et al (1999) Monoclonal antibody exposes three mechanisms underlying the clinical course of multiple sclerosis. Ann Neurol 46:296–304PubMedCrossRefGoogle Scholar
  34. 34.
    Collins DL, Narayanan S, Caramanos Z et al (2000) Relation of cerebral atrophy in multiple sclerosis to severity of disease and axonal loss. Neurology 54 [Suppl 3]: A17[Abstract]Google Scholar
  35. 35.
    van Buchem MA, McGowan JC, Kolson DL et al (1996) Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden. Magn Reson Med 36: 632–636PubMedCrossRefGoogle Scholar
  36. 36.
    Kimura H, Grossman RI, Lenkiski RE, Gonzalez-Scarano F (1996) Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: correlative findings of active versus irreversible plaque disease. AJNR Am J Neuroradiol 17: 1539–1547PubMedGoogle Scholar
  37. 37.
    Pike BG, De Stefano N, Narayanan S et al (1999) Combined magnetization transfer and proton spectroscopic imaging in the assessment of pathologic brain lesions in multiple sclerosis. AJNR Am J Neuroradiol 20: 829–837PubMedGoogle Scholar
  38. 38.
    Werring DJ, Clark CA, Barker GJ et al (1999) Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology 52: 1626–1632PubMedCrossRefGoogle Scholar
  39. 39.
    Filippi M, Iannucci G, Cercignani M et al (2000) A quantitative study of water diffusion in MS lesions and NAWM using echo-planar imaging. Arch Neurol 57:1017–1021PubMedCrossRefGoogle Scholar
  40. 40.
    Cercignani M, Iannucci G, Rocca MA et al (2000) Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI. Neurology 54: 1139–1144PubMedCrossRefGoogle Scholar
  41. 41.
    Nusbaum AO, Tang CY, Wei TC et al (2000) Whole-brain diffusion MR histograms differ between MS subtypes. Neurology 54: 1421–1426PubMedCrossRefGoogle Scholar
  42. 42.
    Yousry TA, Berry I, Filippi M (1998) Functional magnetic resonance imaging in multiple sclerosis. J Neurol Neurosurg Psychiatry 64 (Suppl 1): S85–S87PubMedCrossRefGoogle Scholar
  43. 43.
    Rombouts SARB, Lazeron RHC, Scheltens P et al (1998) Visual activation patterns in patients with optic neuritis: an fMRI pilot study. Neurology 50: 1896–1899PubMedCrossRefGoogle Scholar
  44. 44.
    Reddy H, Narayanan S, Matthews PM et al (2000) Relating axonal injury to functional recovery in MS. Neurology 54: 236–239PubMedCrossRefGoogle Scholar

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© Springer-Verlag Italia 2001

Authors and Affiliations

  • M. Rovaris
  • M. Filippi

There are no affiliations available

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