Abstract
Multiple sclerosis (MS) is characterised pathologically by inflammatory focal demyelination at multiple sites in the central nervous system that recur over time. Clinically it is associated with recurrent attacks from which patients show good recovery in the early stages of the illness, usually followed by a chronic phase of progressive functional deterioration. Recent studies have postulated that the mechanism of injury in multiple sclerosis leading to chronic disability is axonal damage rather than the demyelination itself [1]. As has been shown in patients with focal ischaemic disease [2–5] or brain tumours [6], the axonal injury of MS may be expected to be associated with cortical reorganisation.
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Reddy, H., Arnold, D.L., Matthews, P.M. (2001). Functional Magnetic Resonance Imaging and Multiple Sclerosis: Cortical Reorganisation and Recovery. In: Filippi, M., Arnold, D.L., Comi, G. (eds) Magnetic Resonance Spectroscopy in Multiple Sclerosis. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2109-9_7
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DOI: https://doi.org/10.1007/978-88-470-2109-9_7
Publisher Name: Springer, Milano
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