Functional Magnetic Resonance Imaging and Multiple Sclerosis: Cortical Reorganisation and Recovery

  • H. Reddy
  • D. L. Arnold
  • P. M. Matthews
Part of the Topics in Neuroscience book series (TOPNEURO)


Multiple sclerosis (MS) is characterised pathologically by inflammatory focal demyelination at multiple sites in the central nervous system that recur over time. Clinically it is associated with recurrent attacks from which patients show good recovery in the early stages of the illness, usually followed by a chronic phase of progressive functional deterioration. Recent studies have postulated that the mechanism of injury in multiple sclerosis leading to chronic disability is axonal damage rather than the demyelination itself [1]. As has been shown in patients with focal ischaemic disease [2–5] or brain tumours [6], the axonal injury of MS may be expected to be associated with cortical reorganisation.


Multiple Sclerosis Motor Cortex Expand Disability Status Scale Optic Neuritis Functional Magnetic Resonance Imaging 


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Copyright information

© Springer-Verlag Italia 2001

Authors and Affiliations

  • H. Reddy
  • D. L. Arnold
  • P. M. Matthews

There are no affiliations available

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