Advertisement

Magnetic Resonance Spectroscopy: Fundamentals

  • J. C. McGowan
Part of the Topics in Neuroscience book series (TOPNEURO)

Abstract

Spectroscopic analysis using nuclear magnetic resonance (NMR) has long been employed in the field of chemistry and has more recently found a variety of applications in the biochemically based investigation of human metabolism and pathology. In this chapter the physical basis of NMR and magnetic resonance spectroscopy (MRS) will be briefly outlined, followed by explanations of principles underlying modern applications of MRS to investigations of human pathology in vivo. To the extent possible, the explanations will be confined to terms of classical physics.

Keywords

Nuclear Magnetic Resonance Magnetic Resonance Spectroscopy Transverse Magnetization Nuclear Magnetic Resonance Spectroscopy Free Induction Decay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bloch F (1946) Nuclear induction. Phys Rev 70: 460–474CrossRefGoogle Scholar
  2. 2.
    Hahn EL (1950) Spin echoes. Phys Rev 80: 580–594CrossRefGoogle Scholar
  3. 3.
    Bottomley PA (1984) Selective volume method for performing localized NMR spectroscopy. US Patent 4: 480 228Google Scholar
  4. 4.
    Frahm J, Bruhn H, Gyngell M et al (1989) Localized high resolution proton NMR spectroscopy using stimulated echos: initial application to human brain in vivo. Magn Reson Med 9: 79–93PubMedCrossRefGoogle Scholar
  5. 5.
    Gonen O, Viswanathan A, Catalaa I et al (1998) Total brain N-acetylaspartate concentration in normal, age-grouped females: quantitation with non-echo proton NMR spectroscopy. Magn Reson Med 40: 684–689PubMedCrossRefGoogle Scholar
  6. 6.
    Chance B, Leigh J, Kent I et al (1986) Multiple controls of oxidative metabolism in living tissues as studied by phosphorous magnetic resonance. Proc Natl Acad Sci USA 83: 9458PubMedCrossRefGoogle Scholar
  7. 7.
    Haacke EM, Brown RW, Thompson MR, Venkatesan R (2000) Magnetic resonance imaging: physical principles and sequence design. Wiley, New YorkGoogle Scholar
  8. 8.
    Liang Z, Lauterbur P (2000) Principles of magnetic resonance imaging. IEEE Press, New YorkGoogle Scholar
  9. 9.
    Hoch JC, A.S. S (1996) NMR data processing. Wiley-Liss, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Italia 2001

Authors and Affiliations

  • J. C. McGowan

There are no affiliations available

Personalised recommendations