New Magnetic Resonance Spectroscopy Strategies

  • O. Gonen
  • R. I. Grossman
Part of the Topics in Neuroscience book series (TOPNEURO)


The impetus for the development and implementation of proton magnetic resonance spectroscopy (1H-MRS) in multiple sclerosis (MS) comes from the desire to understand the biochemical nature of the disease. Magnetic resonance (MR) is a highly sensitive but rather nonspecific window on brain pathology. MR specificity is of critical importance to successful correlation of imaging and histopathology. The diverse pathology of MS provides opportunities for multiple treatment strategies. Thus, identifying particular biochemical abnormalities may be viewed as the initial step in categorizing the disease process. MS lesions are disseminated over the entire central nervous system, yet until recently (1996) MRS methodology involved just single-voxel experiments. Although important data can be obtained in this way, much abnormal brain is excluded from the measurement. The following descriptions represent an approach that facilitates metabolic measures on a larger scale. The rationale for three-dimensional (3D) 1H-MRS and whole-brain N-acetylaspartate (WBNAA) quantification is that the diffuse nature of MS necessitates measures that take into account as much brain as possible. Additionally, the 3D 1H-MRS technique enables us to focus on lesions and activity (defined by gadolinium enhancement) in a prospective manner. This chapter will briefly review the current methodology and discuss two new methods utilizing a more global approach to MRS, in vivo brain 1H-MRS methods.


Multiple Sclerosis Magn Reson Image Spectroscopic Imaging Chemical Shift Imaging Magnetic Resonance Spectroscopic Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Italia 2001

Authors and Affiliations

  • O. Gonen
  • R. I. Grossman

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