How Many Patients Really Need Ventricular Resynchronization Therapy?
It has been estimated that heart failure affects 4.6 million patients in the United States and 22.5 million patients all over the world, and an equal number of patients have asymptomatic left ventricular dysfunction with a high risk of developing heart failure . This condition is the primary discharge diagnosis from hospitals in Western countries. Prognosis is poor, with annual mortality ranging from approximately 10% in NYHA class I-II to 25% in NYHA class III-IV. Heart failure is a condition that principally affects the elderly, and with the progressive ageing of the population it is likely that the prevalence of heart failure will continue to increase during the coming years in both developed and developing countries.
KeywordsHeart Failure Chronic Heart Failure Severe Heart Failure NYHA Class Advanced Heart Failure
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Braunwald E, Bristow MR (2000) Congestive heart failure: fifty years of progress. Circulation 102:IV-14-IV-23Google Scholar
Mann DL (1999) Mechanisms and models in heart failure. A combinatorial approach. Circulation 100:999–1008PubMedCrossRefGoogle Scholar
Packer M, Carver JR, Rodeheffer RJ et al (1991) Effect of oral milrinone on mortality in severe chronic heart failure. N Engl J Med 325:1468–1475PubMedCrossRefGoogle Scholar
Massie BM (1998) 15 years of heart-failure trials: what have we learned? Lancet. 352[Suppl]:29–33CrossRefGoogle Scholar
The SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 325:293–302CrossRefGoogle Scholar
Packer M, Bristow MR, Cohn JN et al (1996) The effect of Carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 334:1350–1355CrossRefGoogle Scholar
Pitt B, Zannad F, Remme WJ et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709–717PubMedCrossRefGoogle Scholar
Blanc JJ, Etienne Y, Gilard M et al (1997) Evaluation of different ventricular pacing sites in patients with severe heart failure: results of an acute hemodynamic study. Circulation 96:3273–3277PubMedCrossRefGoogle Scholar
Zaidi M, Robert A, Fesler R et al (1997) Dispersion of ventricular repolarization in dilated cardiomyopathy. Eur Heart J 18:1129–1134PubMedCrossRefGoogle Scholar
Shamin W, Francis DP, Yousufuddin M et al (1999) Intraventricular conduction delay: a prognostic marker in chronic heart failure. Int J Cardiol 70:171–178CrossRefGoogle Scholar
Cazeau S, Ritter P, Lazarus A et al (1996) Multisite pacing for end-stage heart failure: early experience. Pacing Clin Electrophysiol 19:1748–1757PubMedCrossRefGoogle Scholar
Kass DA, Chen C-H, Curry C et al (1999) Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 99:1567–1573PubMedCrossRefGoogle Scholar
Alonso C, Leclercq C, Victor C et al (1999) Electrocardiographic predictive factors of long-term clinical improvement with multisite biventricular pacing in advanced heart failure. Am J Cardiol 84:1417–1421PubMedCrossRefGoogle Scholar
Auricchio A, Klein H, Spinelli J (1999) Pacing for heart failure: selection of patients, techniques and benefits. Eur J Heart Failure 1:275–279CrossRefGoogle Scholar
Leclercq C, Cazeau S, Ritter P et al (2000) A pilot experience with permanent biventricular pacing to treat advanced heart failure. Am Heart J 140:862–870PubMedCrossRefGoogle Scholar
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