A “Post-copernican” Analysis of Intracellular pH

  • S. Magder
Conference paper


Hydrogen ion concentration is one of the most-important regulated aspects of the intracellular environment, since changes in hydrogen ion concentration are associated with alterations in virtually all cell processes. Intracellular pH is typically more acidic than the pH of the extracellular space, and is in the range of 6.8–7.2 [1]. This represents the average pH in the cytoplasm and nucleus, but the pH of intracellular organelles can range from as low as 5.0 in lysosomes to as high as 8.0 in the mitochondria (Fig. 1).


Weak Acid Intracellular Environment Strong Anion Intracellular Volume Stewart Approach 
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Copyright information

© Springer-Verlag Italia 2002

Authors and Affiliations

  • S. Magder
    • 1
  1. 1.Department of Medicine and PhysiologyMcGill University Hospital CentreMontrealCanada

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