Abstract
Hydrogen ion concentration is one of the most-important regulated aspects of the intracellular environment, since changes in hydrogen ion concentration are associated with alterations in virtually all cell processes. Intracellular pH is typically more acidic than the pH of the extracellular space, and is in the range of 6.8–7.2 [1]. This represents the average pH in the cytoplasm and nucleus, but the pH of intracellular organelles can range from as low as 5.0 in lysosomes to as high as 8.0 in the mitochondria (Fig. 1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Putnam RW (1998) Intracellular pH regulation. In: Cell physiology source book, Sperelakis. Academic Press, Cincinnati pp 293–311
Orlowski J, Grinstein S (1997) Na+/H+ exchangers of mammalian cells. J Biol Chem 272: 22373–22376
Stewart PA (1981) How to Understand Acid-Base. A Quantitative Acid-Base Primer for Biology and Medicine. Elsevier New York
Magder S (1998) Pathophysiology of metabolic acid-base disturbances in patients with critical illness. In: Ronco C, Bellorno R (eds.) Crit Care Nephrol Kluwer Academic Publishers, Netherlands 279–296
Heigenhauser GJF Lindinger MI 1988 Ion fluxes during tetanic stimulation in isolated perfused rat hindlimb. Am J Physiol 245 R117–R126
Kowalchuk JM, Heigenhauser GJF, Lindinger MI (1981) Factors influencing hydrogen ion concentration in muscle after intense exercise. J Appl Physiol. 65: 2080–2089
Lindinger MI (1995) Origins of [H+] changes in exercising skeletal muscle. Can J Appl Physiol 20: 357–368
Prange HD, Shoemaker JLJ, Westen EA, et al (2001) Physiological consequences of oxygendependent chloride binding to hemoglobin. J Appl Physiol 91: 33–38
Hochachka PW, Mommsen TP (1983) Protons and anaerobiosis. Science 219: 1391–1397
Neylon CB, Little PJ, Cragoe EJ Jr, Bobik A (1990) Intracellular pH in human arterial smooth muscle: regulation by Na+/H+ exchange and a novel 5-(n-ethyl-n-isopropyl) amiloride-sensitive Na+—and HCO3-—dependent mechanism. Circ Res 67: 814–825
Rawn JD (1989) Bioenergetics: The significance of the hydrolysis of ATP and other energy-rich metabolites. In: Daisy L, Hodgin KC, O’QuinTL, Olsen S and Swan JA. Burlington: Patterson, pp 265–287
Roos A, Boron WF (1981) Intracellular pH. Physiol Rev 61: 296–434
Russell JM (1976) Role of chloride transport in regulation of intracellular pH. Nature 4: 73–74
Counillon L, Pouysségur J (2000) The expanding family of eucaryotic Na /H exchangers. BiolChem 275: 1–4
Grinstein S, Cohen S, Rothstein A (1984) Cytoplasmic pH regulation in thymic lymphocytes by an amiloride-sensitive Na+/H+ Antiport. J Gen Physiol 83: 341–369
Moolenaar WH, Boonstra J, Saag PT van der, de Laat SW (1981) Sodium/proton exchange in mouse neuroblastoma cells. J Biol Chem 256: 12883–12887
Boron WF, Russel JM (1983) Stoichiometry and ion dependencies of the intracellular-pH-regulating mechanism in squid giant axons. J Gen Physiol 81: 373–399
Stevens TH, Forgac M (1997) Structure, function and regulation of the vacuolar (H+)-ATPase. Annu Rev Cell Dev Biol 13: 779–808
Stone DK, Xie X-S (1988) Proton translocating ATPase: issues in structure and function. Kidney International 33: 767–774
Wieczorek H, Brown D, Grinstein S, et al (1999) Animal plasma membrane energization by proton-motive V-ATPases. Biol Essays 21: 637–648
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Italia
About this paper
Cite this paper
Magder, S. (2002). A “Post-copernican” Analysis of Intracellular pH. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2099-3_50
Download citation
DOI: https://doi.org/10.1007/978-88-470-2099-3_50
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0176-3
Online ISBN: 978-88-470-2099-3
eBook Packages: Springer Book Archive