Abstract
The first descriptions of acute respiratory distress syndrome appeared in 1967, when Ashbaugh et al. described 12 patients with acute respiratory distress, cyanosis refractory to oxygen therapy, decreased lung compliance, and diffuse infiltrates evident on the chest radiograph [1] . It is not defined by a specific pathogenesis, but reflects the lung’s nonselective response to numerous insults and precipitating factors. Although the term acute respiratory distress syndrome (ARDS) is often used interchangeably with acute lung injury (ALI), by strict criteria ARDS should be reserved for the most severe end of the spectrum (Table 1) [2].
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References
Ashbaugh DG, Bigelow DB, Petty TL et al (1967) Acute respiratory distress syndrome. Lancet 2: 319–323
Bernard GR, Artigas A, Bringham KL et al (1994). The American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149:818–824
Pepe PE, Potkin RT, Resus DR et al (1982) Clinical predictors of the adult respiratory distress syndrome. Am J Surg 144:124–130
Fein AM, Lippmann M, Hotzman H et al (1983) The risk factors, incidence, and prognosis of ARDS following septicemia. Chest 83:40–42
Bone RC, Grodzin CJ, Balk RA (1997) Sepsis: A new hypothesis for pathogenesis of the disease process. Chest 112: 235–243
Ryan SF (1990) Acute alveolar injury: experimental models. In: Gil J (ed) Models of lung disease. Marcel Dekker, New York, pp 641–733
Williwerth BM, Crawford FA, Young WG et al (1967) The role of functional demand on the development of pulmonary lesions during hemorrhagic shock. J Thorac Cardiovasc Surgery 54: 658–665
Pomerantz M, Eisman B (1968) Experimental shock lung model. J Trauma 8: 782–787
Sealy WC (1968) The lung in hemorrhagic shock. J Trauma 8: 774–781
Cook WA (1968) Experimental shock lung model. J Trauma 8: 793–796
Murray JF, and Staff of Division of Lung Diseases, National Heart, Lung and Blood Institute (1977). Conference Report-Workshop on mechanisms of acute respiratory failure. Am Rev Respir Dis 115: 1071–1078
Windsor ACJ, Mullen PG, Fowler AA (1993) Acute lung injury: What have we learned from animal models. Am J Med Sci 306:111–116
Flick MR (1986) Mechanisms of acute lung injury: What we have learned from experimental animal models. Crit Care Clin 2: 455–470
Staub NC (1971) Steady state transvascular water filtration in unanesthetized sheep. Cir Res 28:135–139
Brigham KL, Woolverton WC, Blake LH et al (1974) Increased sheep lung vascular permeability caused by Pseudomonas bacteremia. J Clin Invest 54: 792–804
Craddock PR, Fehr J, Brigham KL et al (1977) Complement and leukocyte mediated pulmonary dysfunction in hemodialysis. N Engl J Med 296: 769–774
Hammerschmidt DE, Weaver LJ, Hudson LD et al (1980) Association of complement activation and elevated plasma C5a with adult respiratory distress syndrome. Lancet 1: 947–949
Till GO, Johnson KJ, Kunkel R (1982) Intravascular activation of complement and ALI: Dependency on neutrophils and toxic oxygen metabolites. J Clin Invest 60: 1126–1135
Henson PM, Larsen GL, Webster RO et al (1982) Pulmonary microvascular alterations and injury induced by complement fragments: Synergistic effect of complement activation, neutrophil sequestrations and prostaglandins. Ann NY Acad Sci 348: 287–300
Hosea S, Brown E, Hammer C et al (1980) Role of complement activation in a model of adult respiratory distress syndrome. J Clin Invest 66: 375–382
Stevens J, O’Hanley PT, Shapiro J et al (1986) Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J Clin Invest 77: 1812–1816
Rabinovici R, Yah C, Hillegass L et al (1992) Role of complement in endotoxin/platelet activity factor-induced lung injury. J Immunol 149: 1744–1750
Dehring DJ, Steinberg SM, Wismar BL et al (1987) Complement depletion in a porcine model of acute respiratory disease. J Trauma 27: 615–626
Flick MR, Horn JK, Hoellfel JM et al (1986) Reduction in total hemolytic complement activity with Naja haje cobra venom factor does not prevent endotoxin induced lung injury in sheep. Am Rev Respir Dis 133: 62–67
Brigham K, Meyrick B (1986) Endotoxin and lung injury. Am Rev Respir Dis 133: 913–927
Peterson MP, Huttemeier PC, Zapol WM et al (1982) Tromboxane mediates acute pulmonary hypertension in sheep extracorporeal perfusion. Am J Physiol 243: H471-H479
Gnidec AG, Sibbald WJ, Cheung H et al (1988) Ibuprofen reduces the progressive permeability edema in an animal model of hyperdynamic sepsis. J Appl Physiol 65: 1024–1032
Byrne K, Carey PD, Sielaff TD et al (1991) Ibuprofen prevents deterioration in static transpulmonary compliance and transalveolar protein flux in septic porcine acute lung injury. J Trauma 31: 155–166
Garcia JG, Noonan TC, Jubiz W et al (1987) Leukotrienes and the pulmonary microcirculation. Am Rev Respir Dis 136: 161–169.
Gadaleta D, Davis JM (1994) Pulmonary failure and the production of leukotrienes. J Am Coll Surg 178: 309–319
Rabinovici R, Bugelski PJ, Esser KM et al (1993) ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats. J Appl Physiol 74: 1791–1802
Bachofen A, Weibel ER (1977) Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia. Am Rev Respir Dis 116: 589–615
Meyrick B, Ryan US, Brigham KL (1990) Acute effects of Escherichia coli endotoxin on the pulmonary microcirculation of anesthetized sheep. Lab Invest 62: 355–362
Heflin AC, Brigham KL (1981) Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J Clin Invest 68:1253–1260
Shasby DM, Vanbenthugsen KM, Tate RM et al (1982) Granulocyte mediated acute edematous lung injury in rabbits and isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. Am Rev Respir Dis 125: 443–447
Brigham KL, Meyrick B, Berry JC et al (1987) Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin. J Appl Physiol 63:840–850
Hinson J, Hutchison A, Ogletree M et al (1983) Effect of granulocyte depletion on altered lung mechanics after endotoxemia in sheep. J Appl Physiol 55: 92–99
Kelley J (1990) Cytokines of the lung. Am Rev Respir Dis 141: 765–788
Walsh CJ, Sugerman HJ, Mullen PG et al (1992) Monoclonal antibody to tumor necrosis factor ??attenuates cardiopulmonary dysfunction in porcine gram negative sepsis. Arch Surg 127: 138–145
Mulligan MS, Jones ML, Bolanowski MA et al (1993) J Immunol 150: 5585–5595
Sekido N, Mukaida N, Harada A et al (1993) Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 365:654–657
Wakabayashi G, Gelfand JA, Burke J et al (1991) A specific receptor antagonist for interleukin 1 prevents Escherichia coli induced shock in rabbits. FASEB J 5: 338–343
Canonico AE, Brigham KL (1997) Biology of Acute Injury. In Crystal RG, West JB (eds) The Lung. Scientific Foundations. Lippincott-Raven Publishers, Philadelphia, pp 2475–2498
Opal SM, DePalo VA (2000) Impact of basic research on tomorrow’s medicine anti-inflammatory cytokines. Chest 117: 1162–1172
Cassatella MA, Meda L, Bonora S, et al (1993) Interleukin 10 (IL-10) inhibits the release of pro-inflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role for tumor necrosis factor and IL-12 in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 178: 2207–2211
Parsons PE (2000) Mediators and mechanisms of acute lung injury. Clin Chest Med 3: 467–476
Pittet JF, MacKersie RC, Martin TR et al (1997) Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med 155: 1187–1205
Dreyfuss D, Soler P, Basset G et al (1988) High inflation pressure pulmonary edema: respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 137: 1159–1164
Bowton DL, Kong DL (1989) High tidal volume ventilation produces increased lung water in oleic acid injured rabbit lung. Crit Care Med 17: 908–911
Snyder JV, Froese A (1987) The open lung approach: concept and application. In: Snyder JV and Pinsky MR (eds) Oxygen Transport in the Critically 111. Year Book Medical Publishers, Chicago, pp 374–395
Rotta AR, Steinhorn DM (1998) Partial liquid ventilation reduces pulmonary neutrophil accumulation in an experimental model of systemic endotoxemia and acute lung injury. Crit Care Med 10: 1707–1715
Doctor A, Price B, Bhargava N et al (2001) High frequency oscillatory ventilation of the perfluorocarbon-filled lung: dose response relationships in an animal model of acute lung injury. Crit Care Med 29: 847–854
Verbrugge SJC, Uhlig S, Neggers SJCMM et al (1999) Different ventilation strategies affect lung function but do not increase tumor necrosis factor-alpha and prostacyclin production in lavaged rat lungs in vivo. Anesthesiology 91: 1834–1843
Broccard A, Shapiro RS, Schmitz LL et al (2000) Prone positioning attenuates and redistributes ventilator-induced lung injury in dogs. Crit Care Med 28: 295–303
Van der Kloot TE, Blanch L, Youngblood M et al (2000) Recruitment maneuvers in three experimental models of acute lung injury. Effect on lung volume and gas exchange. Am J Respir Crit Care Med 161: 1485–1494
Waugh JB, Op’t Holt TB, Olson LE et al (2000) Surfactant treatment impairs gas exchange in a canine model of acute lung injury. Crit Care Med 28: 2887–2892
Brackenbury AM, Puligandla OS, McCaig LA et al (2001) Evaluation of exogenous surfactant in HCl-induced lung injury. Am J Respir Crit Care Med 163: 1135–1142
Delavai PM, Gillespie DJ (1985) Pulmonary dysfunction during paraquat-induced lung injury: A model of acute alveolar injury. Crit Care Med 13:1056–1060
Smith P, Health D, Kay JM (1974) The pathogenesis and structure of paraquat-induced lung fibrosis in rats. J Pathol 114:57–67
Rocco PRM, Negri EM, Kurtz PM et al (2001) Lung tissue mechanics and extracellular matrix remodeling in acute lung injury. Am J Respir Crit Care Med (in press)
Schuster DP (1994) ARDS: Clinical lessons from the oleic acid model of acute lung injury. Am J Respir Crit Care Med 149:245–260
Derks CM and Jacobovitz-Derks D (1977) Embolic pneumopathy induced by oleic acid. Am J Pathol 87: 143–158
Schoene RB, Robertson HT, Thorning DR et al (1984) Pathophysiological patterns of resolution from acute oleic acid lung injury in the dog. J Appl Physiol 56: 472–481
Johanson WG Jr, Holcomb JR, Coalson J (1982) Experimental diffuse alveolar damage in baboons. Am Rev Respir Dis 126: 142–151
Furue S, Mikawa K, Nishina K et al (2001). Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection. Crit Care Med 29: 719–727
Enrione MA, Papo MC, Leach CL, et al (1999) Regional pulmonary blood flow during partial liquid ventilation in normal and acute oleic acid-induced lung injured piglets. Crit Care Med 27: 2716–2723
Lachmann B, Robertson B, Vogel J (1980) In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesthesiol Scand 24: 231–236
Brigham K, Bowers R, Haynes J (1979) Increased sheep lung vascular permeability caused by E. coli endotoxin. Circulation 45: 292–297
Van Helden HP, Kuijpers WC, Steenvoorden D et al (1997) Intratracheal aerolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome. Exp Lung Res 23: 297–316
Rotta AT, Gunnarsson B, Hernan LJ et al (1999) Partial liquid ventilation influences pulmonary histopathology in an animal model of acute lung injury. J Crit Care 14: 84–92
Faffe DS, Scidl VR, Chagas PSC, Gonçalves de Moraes VL, Capelozzi VL, Rocco PRM, Zin WA (2000) Respiratory effects of lipopolysaccharide-induced inflammatory lung injury in mice. Eur Respir J 15: 85–91
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Rocco, P.R.M., Zin, W.A. (2002). Experimental Models of Acute Lung Injury. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2099-3_15
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DOI: https://doi.org/10.1007/978-88-470-2099-3_15
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