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Idiopathic Inflammatory Myopathies: Immunological Aspects

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Autoantibodies in Neurological Diseases

Part of the book series: Topics in Neuroscience ((TOPNEURO))

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Abstract

Muscle inflammation is generally termed “myositis” whether the aetiology is known (viral, bacterial or parasitic) or unknown (idiopathic). The inflammatory myopathies are a heterogeneous group of subacute/chronic muscle disorders sharing a common characteristic muscle degeneration mediated by inflammatory mechanisms [1]. This review will be concerned with the main pathogenetic features of the three major inflammatory myopathies: dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). The latter includes sporadic (s-IBM) and hereditary inclusion body myopathy (h-IBM), which is an a hereditary progressive muscle disease with muscle pathology similar to the s-IBM,but lacking lymphocytic inflammation [2].

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Authors and Affiliations

  1. Myopathology and Immunology Unit, Department of Neuromuscular Diseases, National Neurological Institute “Carlo Besta”, Via Celoria 11, 20133, Milan, Italy

    R. Mantegazza & P. Bernasconi

  2. Department of Neuromuscular Diseases, National Neurological Institute “Carlo Besta”, Via Celoria 11, 20133, Milan, Italy

    F. Cornelio

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  1. R. Mantegazza
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Editors and Affiliations

  1. Neurosciences Group, Department of Clinical Neurology, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK

    Angela Vincent

  2. Neuroimmunology Unit, Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

    Gianvito Martino

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Mantegazza, R., Bernasconi, P., Cornelio, F. (2002). Idiopathic Inflammatory Myopathies: Immunological Aspects. In: Vincent, A., Martino, G. (eds) Autoantibodies in Neurological Diseases. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2097-9_7

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