Idiopathic Inflammatory Myopathies: Immunological Aspects

  • R. Mantegazza
  • P. Bernasconi
  • F. Cornelio
Part of the Topics in Neuroscience book series (TOPNEURO)


Muscle inflammation is generally termed “myositis” whether the aetiology is known (viral, bacterial or parasitic) or unknown (idiopathic). The inflammatory myopathies are a heterogeneous group of subacute/chronic muscle disorders sharing a common characteristic muscle degeneration mediated by inflammatory mechanisms [1]. This review will be concerned with the main pathogenetic features of the three major inflammatory myopathies: dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). The latter includes sporadic (s-IBM) and hereditary inclusion body myopathy (h-IBM), which is an a hereditary progressive muscle disease with muscle pathology similar to the s-IBM,but lacking lymphocytic inflammation [2].


Major Histocompatibility Complex Class Muscle Biopsy Inclusion Body Myositis Inflammatory Myopathy Idiopathic Inflammatory Myopathy 


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Copyright information

© Springer-Verlag Italia 2002

Authors and Affiliations

  • R. Mantegazza
    • 1
  • P. Bernasconi
    • 1
  • F. Cornelio
    • 2
  1. 1.Myopathology and Immunology Unit, Department of Neuromuscular DiseasesNational Neurological Institute “Carlo Besta”MilanItaly
  2. 2.Department of Neuromuscular DiseasesNational Neurological Institute “Carlo Besta”MilanItaly

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