New Antibodies to Neuronal and Muscle Antigens
The role of antibodies to ion channels at the neuromuscular junction is now well established. Antibodies binding to the muscle isoform of the acetylcholine receptor (AChR) are present in the majority of patients with myasthenia gravis (MG; see Chaps. 2,4), and antibodies binding to the voltage-gated calcium channel in the Lambert-Eaton myasthenic syndrome (LEMS; see Chap. 3). However, the recognition of the role these antibodies play in the pathogenesis of the disorders, and their usefulness for their diagnosis, stimulated the search for other antibody-mediated diseases of the peripheral nervous system, and also raised questions concerning their possible involvement in central nervous system (CNS) diseases (see the Introduction to this volume).
KeywordsCerebellar Ataxia Maternal Antibody TE671 Cell Limbic Encephalitis AChR Cluster
Unable to display preview. Download preview PDF.
- 7.Plested CP (1999) Mechanism of action of seronegative myasthenia. DPhil thesis. University of OxfordGoogle Scholar
- 11.Hall JG, Vincent A (2001) Arthrogryposis. In: Jones HR, De Vivo DC, Darras BT (eds) Neuromuscular disorders of infancy and childwood. Butterworth-Heinemann, Woburn, USA (in press)Google Scholar
- 18.Polizzi A, Huson SM, Vincent A (2000) Teratogen update: maternal myasthenia gravis as a cause of congenital arthrogryposis.Teratology 62:332–341Google Scholar
- 20.Vincent A, Matthews I, Newsom-Davis J, Willcox N (2000) Antibodies to fetal acetylcholine receptors in parous women. Ann Neurol 48:479 (abs)Google Scholar
- 24.Hart IK (2000) Acquired neuromyotonia: a new autoantibody-mediated neuronal potassium channelopathy Am J Med Sci 319:209–216Google Scholar
- 27.Liguori R, Vincent A, Clover L et al (2001) Morvan’s syndrome: peripheral and central nervous and cardiac involvement with antibodies to voltage-gated potassium channels and altered circadian rhythyms. Brain (in press)Google Scholar
- 29.Buckley C, Oger J, Clover L et al (2001) Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol 50:74–79Google Scholar