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Opsoclonus-Myoclonus Syndrome in Childhood

  • Chapter
Autoantibodies in Neurological Diseases

Part of the book series: Topics in Neuroscience ((TOPNEURO))

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Abstract

In 1962 Kinsbourne described six infants with a syndrome of myoclonus and “dancing eyes” (opsoclonus-myoclonus syndrome, OMS) [1]. OMS in association with neuroblastoma [2] and other neural-crest-derived tumours has been described in some children (paraneoplastic OMS, OMS-NB+), whilst several other potential causal relationships have also been found (Table 1), but little progress has been made in understanding the etiology and treatment of this syndrome. Recently, however, there has been increasing evidence that OMS may be an autoimmune disease of the central nervous system. This chapter will describe the clinical and immunological features as well as treatment options of OMS.

Table 1 Neurological diseases characterized by epilepsy and autoantibodies
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Author information

Authors and Affiliations

  1. Department of Neurology, Justus-Liebig University, Giessen, Germany

    F. Blaes

  2. Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK

    B. Lang

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  1. F. Blaes
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  2. B. Lang
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Editors and Affiliations

  1. Neurosciences Group, Department of Clinical Neurology, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK

    Angela Vincent

  2. Neuroimmunology Unit, Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

    Gianvito Martino

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© 2002 Springer-Verlag Italia

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Blaes, F., Lang, B. (2002). Opsoclonus-Myoclonus Syndrome in Childhood. In: Vincent, A., Martino, G. (eds) Autoantibodies in Neurological Diseases. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2097-9_12

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  • DOI: https://doi.org/10.1007/978-88-470-2097-9_12

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2163-1

  • Online ISBN: 978-88-470-2097-9

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