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Introduction - Approaches to Understanding Immune-Mediated Neurological Disorders: Measuring and Evaluating Autoantibodies to Neuronal Antigens

  • G. Martino
  • A. Vincent
Part of the Topics in Neuroscience book series (TOPNEURO)

Abstract

There is increasing evidence of the relevance of the immune system to the pathogenesis of a variety of neurological disorders, including neuromuscular junction disorders, immune-mediated demyelinating disorders, and also some form of epilepsy, stroke, Alzheimer’s and Parkinsons’ diseases, and prion diseases. It is, therefore, particularly important to distinguish those conditions which are caused by dysfunction of the immune system, from those in which immune responses play a purely secondary role. In this chapter, we first provide an abbreviated introduction to neuroimmunology, and then discuss ways of measuring immune responses to neuronal antigens, and of approaches that evaluate their pathogenic roles.

Keywords

Major Histocompatibility Complex Molecule Experimental Autoimmune Neuritis Major Histocompatibility Complex Expression Neuronal Antigen Deep Cervical Lymph Node 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2002

Authors and Affiliations

  • G. Martino
    • 1
  • A. Vincent
    • 2
  1. 1.Neuroimmunology Unit, Deptartment of Neuroscience, San Raffaele Scientific InstituteDIBITMilanItaly
  2. 2.Neurosciences Group, Department of Clinical Neurology, Institute of Molecular MedicineJohn Radcliffe HospitalOxfordUK

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