Due its relative low cost, safety and availability, conventional ultrasound (US) remains the most widely used cross-sectional imaging modality in routine clinical practice worldwide. Recent advances in nonlinear imaging together with a whole new generation of echo-enhancing agents have improved the clinical applications of US. Indeed there are now increasing reports of single-and multicenter studies confirming improved detection and characterization of focal liver lesions with contrast-enhanced US (Albrecht et al. 2001; Bernatik et al. 2001; Needleman et al. 2000; Wilson et al. 2000; Leen et al. 2002a). In a study comparing unenhanced versus contrast-enhanced US in the detection of liver metastases, the average number of confirmed metastases increased from 3.06 to 5.42 following contrast administration; the sensitivity for detecting individual metastases significantly improved from 63% to 91 %.


Hepatocellular Carcinoma Liver Metastasis Liver Resection Primary Biliary Cirrhosis Focal Liver Lesion 
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© Springer-Verlag Italia 2003

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  • E. Leen

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