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Macro- and Microcirculation of Focal Liver

  • Chapter
Contrast-Enhanced Ultrasound of Liver Diseases

Abstract

Ultrasound (US) plays a secondary role to computed tomography (CT) in the diagnostic assessment of traumatic lesions involving abdominal organs, especially in the case of major trauma (Becker et al. 1998; Boioli et al. 1993; Brown et al. 1998; Harris et al. 2001; Mirvis 2000; Sherck et al. 1984; Shuman 1997). Because US has a relatively limited panoramic capacity, it does not detect lesions of hollow internal organs reliably. On the whole it has a lower sensitivity and specificity than CT in the diagnosis of parenchymal damage to the liver, kidney and spleen.

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References

  • Basilico R, Blomley MJ, Harvey CJ, et al (2002): Which continuous US scanning mode is optimal for the detection of vascularity in liver lesions when enhanced with a second generation contrast agent? Eur J Radiol 41:184–191

    Article  Google Scholar 

  • Becker CD, Mentha G, Terrier F (l998): Blunt abdominal trauma in adults: role of CT in the diagnosis of visceral injuries. Part 1: liver and spleen. Eur Radiol 8:553–562

    Article  Google Scholar 

  • Boioli F, Gattoni F, Tagliaferri B, et al (1993): Role of computed tomography in splenic blunt trauma. Radiol Med 85:213–217

    Google Scholar 

  • Brown M, Casola G, Sirlin CB (2001) Blunt abdominal trauma: screening US in 2693 patients. Radiology 218:352–358

    CAS  PubMed  Google Scholar 

  • Brown SL, Hoffman DM, Spirnak JP (1998) Limitations of routine spiral computerized tomography in the evaluation of blunt renal trauma. J Urol 160:1979–1981

    Article  Google Scholar 

  • Burns PN, Powers JE, Simpson DH, et al. (1996) Harmonic imaging with ultrasound contrast agents Clin Radiol 51 [Suppl 1]:50–55

    Google Scholar 

  • Burns PN, Wilson SR, MD, Simpson DH (2000) Pulse inversion imaging of liver blood flow: improved method for characterizing focal masses with microbubble contrast. Invest Radiol 35:58–71

    Article  Google Scholar 

  • Del Favero C, Martegani A, Aiani L, et al Liver imaging: to break or not to break the microbubbles? Syllabus Bubbles in Radiology - the State of the Art. The Second Symposium on Ultrasound Contrast for Radiological Diagnosis 44-51; Oct 22-232000, Toronto, Canada

    Google Scholar 

  • Dulchavsky SA, Henry SE, Moed BR, et al (2002) Advanced ultrasonic diagnosis of extremity trauma: the FASTER examination. J Trauma 53:28–32

    Article  Google Scholar 

  • Freeman P (1999) The role of ultrasound in the assessment of the trauma patient Aust J Rural Health 7:85–89

    CAS  Google Scholar 

  • Harris AC, Zwirewich CV, Liburn ID, et al (2001) CT findings in blunt renal trauma. Radiographics 21:201–214

    Google Scholar 

  • Kirkpatrick AW, Simons RK, Brown R, et al (2002) The hand-held FAST: experience with hand-held trauma sonography in a level-I urban trauma center. Injury 33:303–308

    Article  Google Scholar 

  • Krupnick AS, Teitelbaum DH, Geiger JD, et al (1997) Use of abdominal sonography to assess pediatric splenic trauma. Potential pitfalls. Ann Surg 225:408–414

    Google Scholar 

  • Lenz KA, McKenney MG, Numez DB Jr, et al (1996) Evaluating blunt abdominal trauma: role for ultrasonography. J Ultrasound Med 15:447–451

    Google Scholar 

  • Lingawi SS, Buckeley AR (2000) Focused abdominal US in patients with trauma Radiology 217:426–429

    Google Scholar 

  • Mattrey RF, Pelura TJ (1997) Perfluorocarbon-based ultrasound contrast agents. In: Goldberg BB (ed) Ultrasound contrast agens. Martin Dunits, pp 83–87

    Google Scholar 

  • McGahan JP, Richards JR, Jones CD, et al (1999) Use of ultrasonography in patients with acute renal trauma. J Ultrasound Med 18(3):207–213

    CAS  PubMed  Google Scholar 

  • Mirvis SE (2000) Role of CT in diagnosis and management of spleen injury. Appl Radiol 29:7–12

    Article  Google Scholar 

  • Porter RS, Nester BA, Dalsey WC, et al (1997) Use ofultrasound to determine need for laparotomy in trauma patients. Ann Emerg Med 29:323–330

    Article  CAS  PubMed  Google Scholar 

  • Richardson MC, Hollman AS, Davis CF (1997) Comparison of computed tomography and ultrasonographic imaging in the assessment of blunt abdominal trauma in children. Br J Surg; 84: 1144–1146

    Article  Google Scholar 

  • Sherck JP, McCort JJ, Oakes DD (1984) Computed tomography in thoracoabdominal trauma. J Trauma 24:1015–1021

    Article  Google Scholar 

  • Shuman WP (l997) CT of blunt abdominal trauma in adults. Radiology 205:297–306

    Google Scholar 

  • Weill F, Rohmer P, Didiel D, et al (l988) Ultrasound of the traumatized spleen; left butterfly sign in lesions masked by echogenic blood clots. Gastrointestinal Radiol 13:169–172

    Article  Google Scholar 

  • Basilico R, Blomley MJ, Harvey CJ, Filippone A, Heckemann RA, Eckersley RJ, Cosgrove DO (2002). Which continuous US scanning mode is optimal for the detection of vascularity in liver lesions when enhanced with a second generation contrast agent? Eur J Radiol 41:184–91

    Article  Google Scholar 

  • Bums PN, Powers JE, Simpson DH, et al (l996) Harmonic imaging with ultrasound contrast agents Clin Radiol 51 [Suppl 1]:50–55

    Google Scholar 

  • Burns PN, Wilson SR, MD, Simpson DH (2000) Pulse inversion imaging of liver blood flow: improved method for characterizing focal masses with microbubble contrast. Invest Radiol 35:58–71

    Article  Google Scholar 

  • Del Favero C, Martegani A, Aiani L, et al (2000) Liver imaging: to break or not to break the microbubbles? Syllabus Bubbles in radiology - the state of the art. The Second Symposium on Ultrasound Contrast for Radiological Diagnosis, Toronto, Canada, pp 44–51

    Google Scholar 

  • Freeny PC, Marks WM (l986) Hepatic hemangioma: dynamic bolus CT. AJR Am J Roentgenol 147:711–19

    Article  Google Scholar 

  • Gandolfi L, Leo P, Solmi L et al (l991) Natural history of hepatic hemangiomas: clinical and ultrasound study. Gut 32:677

    Article  Google Scholar 

  • Heiken JP, Weyman PJ, Lee JKT et al (l989) Detection of focal hepatic masses: prospective evaluation with CT, delayed CT, CT during arterial portography and MRI. Radiology 171:47–52

    Google Scholar 

  • Jang HJ, Choi BI, Kim TK et al (l998) Atypical small hemangiomas of the liver: “bright dot” sign at twophase spiral CT. Radiology 208:543–548

    Google Scholar 

  • Jang HJ, Lim HK, Lee WJ et al. (2000) Ultrasonographic evaluation of focal hepatic lesions: comparison of pulse inversion harmonic and conventional imaging techiniques. J Ultrasound Med 19(5):293–299; quiz 301-302

    Google Scholar 

  • Kim KW, Kim TK, Han JK et al (2000) Hepatic hemangiomas: spectrum of US appearances on gray-scale, power Doppler, and contrast-enhanced US. Korean J Radiol 1:191–197

    Google Scholar 

  • Kim TK, Choi BI, Han JK et al, (2000) Hepatic tumors: contrast agent enhancement patterns with pulse inversion harmonic US. Radiology 216, 411–417

    Google Scholar 

  • Marm MA, Bree RL, Siver TM (1991) Ultrasonography of the liver: technique and focal and diffuse disease. Radiol Clin N Am 29:1151

    Google Scholar 

  • Mirk P, Rubaltelli L, Bazzocchi M, et al (l982) Ultrasonographic patterns in hepatic hemangiomas. J Clin Ultrasound 10:373–378

    Article  Google Scholar 

  • Moody AR, Wilson SR (l993) Atypical hepatic hemangioma: a suggestive sonographic morphology. Radiology 188:413–417

    Google Scholar 

  • Onodera H, Ohta K, Oikawa M, et al (l983) Correlation of the real-time ultrasonographic appearance of hepatic hemangiomas with angiography. J Clin Ultrasound 11:421–425

    Article  Google Scholar 

  • Tanaka S, Kitamura T, Fuijta M et al (1987) Color Doppler flow imaging of liver tumors. AJR 154:509

    Article  Google Scholar 

  • Unal O, Sakarya ME, Arslan H et al (2002) Hepatic cavernous hemangiomas: patterns of contrast enhancement on MR fluoroscopy imaging. Clin Imaging 26:39–42

    Article  Google Scholar 

  • Van Beers BE, Gallez B, Pringot J (l997) Contrast-enhanced MR imaging of the liver. Radiology 203:297–306

    Google Scholar 

  • Van Leeuwen MS, Noordzij J, Feldberg MAM, et al (l996) Focal liver lesions: characterization with triphasic spiral CT. Radiology 201:327–36

    Google Scholar 

  • Yun EJ, Choi BI, Han JK, et al (l999) Hepatic hemangioma: contrast-enhancement pattern during the arterial and portal venous phases of spiral CT. Abdom Imaging 24:262–266

    Article  Google Scholar 

  • Lee JY, Choi BI, Han JK, et al (2002) Improved sonographic imaging of hepatic hemangioma with contrast-enhanced coded harmonic angiography: comparison with MR imaging. Ultrasound Med Biol 28(3):287–95

    Article  Google Scholar 

  • Leen E (2001) The role of contrast-enhanced ultrasound in the characterisation of focal liver lesions. Eur Radiol 11 [Suppl 3]:E27–34

    Article  Google Scholar 

  • Leen E, Angerson WJ, Yarmenitis S, (2002) et al Multicentre clinical study evaluating the efficacy of SonoVue (BRl), a new ultrasound contrast agent, in Doppler investigation of focal hepatic lesions. Eur J Radiol 41:200–206

    Article  Google Scholar 

  • Quaia E, Bertolotto M, Dalla Palma L, (2002) Characterization of liver hemangiomas with pulse inversion harmonic imaging. Eur Radiol 12:537–544

    Google Scholar 

  • Wilson SR, Bums PN, Muradali D, et al (2000) Harmonic hepatic US with microbubble contrast agent: initial experience showing improved characterization of hemangioma, hepatocellular carcinoma and metastasis. Radiology 215 (1):153–161

    Google Scholar 

  • Bartolozzi C, Cioni D, Donati F, Lencioni R (2001) Focal liver lesions: MR imaging-pathologic correlation. Eur Radiol 11:1374–1388

    Article  Google Scholar 

  • Chung KY, Mayo-Smith WW, Saini S, et al (1995) Hepatocellular adenoma: MR imaging features with pathologic correlation. AJR 165:303–308

    Article  Google Scholar 

  • Golli M, Van Nhieu JT, Mathieu D, et al (1994) Hepatocellular adenoma: color Doppler US and pathologic correlations. Radiology 190:741–744

    Google Scholar 

  • Grazioli L, Federle MP, Ichikawa T, et al (2000) Liver adenomatosis: clinical, histopathologic and imaging findings in 15 patients. Radiology 216:395–402

    Google Scholar 

  • Ichikawa T, Federle MP, Grazioli L, Nalesnik M (2000) Hepatocellular adenoma: multiphasic CT and histopathologic findings in 25 patients. Radiology 214:861–868

    Google Scholar 

  • Ros PR, Menu Y, Vilgrain V, Mortele KJ, Terris B (2001) Liver neoplasms and tumor-like conditions. Eur Radiol 11 [Suppl 2] S145–S165

    Google Scholar 

  • Dill-Macky MJ, Burns PN, Khalili K, Wilson SR (2002) Focal hepatic masses: enhancement patterns with SHU 508A and pulse-inversion US. Radiology 222:95–102

    Article  Google Scholar 

  • Leen E (2001) The role of contrast enhanced ultrasound in the characterisation of focal liver lesions. Eur Radiol 11 [Suppl 3]:E27–34

    Article  Google Scholar 

  • Akhan O, Pringot J (2002) Imaging of abdominal tuberculosis. Eur Radiol 12:321–323

    Article  Google Scholar 

  • Anthony P, Ishak K, Nayak N (1978) The morphology of cirrhosis. Recommendation on definition, nomenclature and classification by a working group sponsored by WHO. J Clin Pathol 31:395–401

    Article  Google Scholar 

  • Apecella PL, Mirowitz SA, Weinreb JC (1994) Extension of vessel through hepatic neoplasms: MR and CT findings. Radiology 191:135–140

    Google Scholar 

  • Brauner M, Buffard MD, Jaentils V, Legrand I (1989) Sonography and computed tomography of macroscopic tuberculosis of the liver. J Clin Ultrasound 17:563–568

    Article  Google Scholar 

  • Coffin CM, Watterson J, Priest JR, Dehner LP (1995) Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19:859–872

    Google Scholar 

  • Fukuya T, Honda H, Matsumata T, et al (1994) Diagnosis of inflammatory pseudotumor of the liver: value of CT. AJR 163:1087–1091

    Article  Google Scholar 

  • Horiuchi R, Uchida T, Kojima T (1990) Inflammatory pseudotumor of the liver. Clinicopathologic study and review of the literature. Cancer 65:1583–1590

    Google Scholar 

  • Hulnick DH, Megibow AJ, Naidich DP, Hilton zS, Cho KC, Balthazar EJ (1985) Abdominal tuberculosis: CT evaluation. Radiology 157:199–204

    Google Scholar 

  • Itai Y, Saida Y (2002) Pitfalls in liver imaging. Eur Radiol 12:1162–1174

    Article  Google Scholar 

  • Kawamori Y, Matsui O, Takahashi S, Kadoya M, Takashima T, Miyayama S (1996) Focal hepatic fatty infiltration in the posterior edge of the medial segment associated with aberrant gastric venous drainage: CT, US, and MR findings. J Comput Assist Tomogr 20:356–359

    Article  Google Scholar 

  • Kelekis NL, Warshauer DM, Semelka RC, Eisenberg LB, Woosley JT (1995) Inflammatorypseudotumor of the liver: appearance on contrast enhanced helical CT and dynamic MR images. J Magn Reson Imaging 5:551–553

    Article  Google Scholar 

  • Kroncke TJ, Taupitz M, Kivelitz D (2000) Multifocal nodular fatty infiltration of the liver mimicking metastatic disease on CT: imaging findings using MR imaging. Eur Radiol 10:1095–1100

    Article  Google Scholar 

  • Levine C (1990) Primary macronodular hepatic tuberculosis: US and CT appearances. Gastrointest Radiol 15:307–309

    Article  CAS  PubMed  Google Scholar 

  • Liessi G, Mastropasqua G, Spaliviero B, Butini R, Pavanello M (1995) Pseudotumore del fegato: imaging con ecografia, Tomografia Computerizzata e Risonanza Magnetica in un caso. Radiol Med 89:545–548

    Google Scholar 

  • Nam KJ, Kang HK, Lim JH (1996) Inflammatory pseudotumor of the liver: CT and sonographic features. AJR 167:485–487

    Article  Google Scholar 

  • Paulson EK, Baker ME, Spritzer CE, Leder RA, Gulliver DJ, Meyers WC (1993) Focal fatty infiltration: a cause of nontumourous defects in the left hepatic lobe during CT arterial portography. J Comput Assist Tomogr 17:590–595

    Article  Google Scholar 

  • Rubaltelli L, Savastano S, Khadivi J, Stramare R, Tregnaghi A, Da Pian P (2002) Targetlike appearance of pseudotumors in segment IV of the liver on sonography. AJR 178(1):75–77

    Article  Google Scholar 

  • Thoeni RF, Margulis AR (1979) Gastrointestinal tuberculosis: Semin Roentgenol 14:283–294

    Article  Google Scholar 

  • Zamir D, Jarchwksy J, Singer C, et al (1998) Inflammatory pseudotumor of the liver. A rare entity and a diagnostic challenge. Am J Gastroenterol 38:1538–1540

    Google Scholar 

  • Baron RL, Oliver JH 3rd, Dodd GD 3rd, Nalesnik M, Holbert BL, Carr B (1996) Hepatocellular carcinoma: evaluation with biphasic, contrast-enhanced, helical CT. Radiology 199:505–511

    Google Scholar 

  • Bartolozzi C, Lencioni R, Donati F, Cioni D (1999) Abdominal MR: liver and pancreas. Eur Radiol 9:1496–1512

    Article  Google Scholar 

  • Bertolotto M, Dalla Palma L, Quaia E, Locatelli M (2000) Characterization of unifocal liver lesions with pulse inversion harmonic imaging after Levovist injection: preliminary results. Eur Radiol 10:1369–1376

    Article  Google Scholar 

  • Blomley MJK, Sidhu PS, Cosgrove DO, et al (2001) Do different types ofliver lesions differ in their uptake of the microbubble contrast agent SHU 508A in the late liver phase ? Early experience. Radiology 220:661–667

    Google Scholar 

  • Bluernke DA, Paulson EK, Choti MA, De Sena S, Clavien PA (2000) Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT. AJR 175:1653–1658

    Article  Google Scholar 

  • Bruix J, Sherma M, Llovet JM, et al (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona 2000 EASL Conference. J Hepatol 35:421–430

    Google Scholar 

  • Choi BI, Park JH, Kim BH, Kim SH, Han MC, Kim CW (1989) Small hepatocellular carcinoma: detection with sonography, computed tomography (CT), angiography and lipiodol-CT. Br J Radiol 62:897–903

    Article  Google Scholar 

  • Choi BI, Kim AY, Lee JY, et al (2002) Hepatocellular carcinoma. Contrast enhancement with Levovist. J Ultrasound Med 21:77–84

    Google Scholar 

  • Dill-Macky MJ, Burns PN, Khalili K, Wilson SR (2002) Focal hepatic masses: enhancement patterns with SHU 508A and pulse-inversion US. Radiology 222:95–102

    Article  Google Scholar 

  • Efremidis SC, Hytiroglou P (2002) The multistep process of hepatocarcinogenesis in cirrhosis with imaging correlation. Eur Radiol 12:753–764

    Article  Google Scholar 

  • Kojiro M, Nakashima O. (1999) Histopathologic evaluation of hepatocellular carcinoma with special reference to small early stage tumors. Semin Liver Dis 19:287–296

    Article  Google Scholar 

  • Kudo M. (1999) Imaging diagnosis of hepatocellular carcinoma and premalignantlborderline lesions. Semin Liver Dis. 19:297–306

    Article  Google Scholar 

  • Leen E (2001) The role of contrast-enhanced ultrasound in the characterization of focal liver lesions. Eur Radiol; 11[Suppl 3]:E27–E34

    Article  Google Scholar 

  • Lim JH, Choi D, Cho SK, et al (2001) Conspicuity of hepatocellular nodular lesions in cirrhotic livers at ferumoxides-enhanced MR imaging: importance of Kupffer cell numbers. Radiology 220:669–676

    Article  Google Scholar 

  • Matsui O, Itai Y (1992). Diagnosis of primary liver cancer by computed tomography. In: Tobe T, Kameda H, Okudaira M et al, (eds) Primary liver cancer in Japan. Springer-Verlag, Tokyo, pp 132–147

    Google Scholar 

  • Matsuo M, Kanematsu M, Itoh K, et al (2001) Detection of malignant hepatic tumors: comparison of gadolinium and ferumoxides-enhanced MR imaging. AJR 177:637–643

    Article  Google Scholar 

  • Numata K, Tanaka K, Kiba T, et al ( 2001) Contrast-enhanced, wide-band harmonic gray-scale imaging of hepatocellular carcinoma. J Ultrasound Med 20:89–98

    Google Scholar 

  • Solbiati L, Cova L, Ierace T, Marelli P, Osti V, Goldberg SN (2000) The importance of arterial phase imaging for wideband harmonic sonography for the characterization of focal lesions in liver cirrhosis using a second generation contrast agent. Radiology 217:305

    Google Scholar 

  • Solbiati L, Tonolini M, Cova L, Goldberg SN (2001) The role of contrast-enhanced ultrasound in the detection of focal liver lesions. Eur Radiol 11[Suppl 3]:E15–E26

    Article  Google Scholar 

  • Tanaka S, Ioka T, Oshikawa O, Hamada Y, Yoshioka F (2001) Dynamic sonography of hepatic tumors. AJR 177:799–805

    Article  Google Scholar 

  • Wilson SR, Burns PN, Murdali D, et al (2000) Harmonic hepatic US with microbubbles contrast agent: initial experience showing improved characterisation of haemangioma, hepatocellular carcinoma and metastasis. Radiology 215:147–151

    Google Scholar 

  • Basilico R, Blomley MJ, Harvey CJ, Filippone A, Heckemann RA, Eckersley RJ, Cosgrove DO (2002) Which continuous US scanning mode is optimalfor the detection of vascularity in liver lesions when enhanced with a second generation contrast agent? Eur J Radiol 41:184–191

    Article  Google Scholar 

  • Bernatik T, Strobel D, Hahn EG, Becker D (2001) Detection of liver metastases: comparison of contrastenhanced wide-band harmonic imaging with conventional ultrasonography. Ultrasound Med 20:509–515

    Google Scholar 

  • Blomely MJK, Albrecht T, Cosgrove DO (1999) Improved imaging ofliver metastases with stimulated acoustic emission in the late phase of enhancement with US contrast agent SHU 563 A; early experience. Radiology 210:409–416

    Google Scholar 

  • Brunetton IN, Raffelli C, Balu-Maestro C, et al (1996) Sonographic diagnosis of solitary solid liver nodules in cancer patients. Eur Radiol 6:439–442

    Google Scholar 

  • Burns PN, Powers JE, Simpson DH, et al (1996) Harmonic imaging with ultrasound contrast agents. Clin Radiol 51 [Suppl 1]:50–55

    Google Scholar 

  • Burns PN, Wilson SR, MD, Simpson DH (2000) Pulse inversion imaging of liver blood flow: improved method for characterizing focal masses with microbubble contrast. Invest Radiol 35:58–71

    Article  Google Scholar 

  • Cosgrove DO, Bolondi L (1999) Malignant liver disease. In: Cosgrove DO (ed) Abdominal and general ultrasound. Churchill Livingstone, New York, pp 27l–293

    Google Scholar 

  • Hagspiel KD, Neidl KFW, Eichenberger AC, et al. (l995) Detection ofliver metastases: comparison of superpararnagnetic iron oxide-enhanced and unenhanced MR imaging at 1,5 T with dynamic CT, intraoperative US, and percutaneous US. Radiology 196:471–478

    Google Scholar 

  • Harvey CJ, Blomely MJK, Eckersley H, et al (2000a) Hepatic malignancies: improved detection with pulse inversion US in late phase with SHU 508 A; early experience. Radiology 216:903–908

    CAS  PubMed  Google Scholar 

  • Harvey CJ et al (2000b) Pulse inversion mode imaging of liver specific microbubbles. Improved detection of subcentimeters metastases. Lancet 335

    Google Scholar 

  • Harvey CJ Albrecht T (2001) Ultrasound of focal liver lesions. Eur Radiol 11:1578–1593

    Article  Google Scholar 

  • Hollett MD, Jeffrey RB, Nino-Murcia M et al (1995) Dual-phase helical CT of the liver: value of arterial phase scans in the detection of small (less than 1.5 cm) malignant hepatic neoplasms AJR 164:879–884

    Google Scholar 

  • Kim TK, Choi BI, Hong HS, et al (2000) Improved imaging of hepatic metastases with delayed pulse inversion harmonic imaging using a contrast agent SH U 508A: preliminary study. Ultrasound Med Biol 26:1439–1444

    Article  Google Scholar 

  • Leen E, Angerson WJ, Yarmenitis S, Bongartz G, Blomley M, Del Maschio A, Summaria V, Maresca G, Pezzoli C, Llull JB (2002) Multi-centre clinical study evaluating the efficacy of Sono Vue (BRl), a new ultrasound contrast agent in Doppler investigation of focal hepatic lesions. Eur J Radiol 41:200–206

    Article  Google Scholar 

  • Lin ZY, Wang LY, Wang JH, et al (1997) Clinical utility of color Doppler sonography in the differentiation of hepatocellular carcinoma from metastases and hemangioma. J Ultrasound Med 16:51–58

    Google Scholar 

  • Mattrey RF, Pelura TJ (1997) Perfluorocarbon-based ultrasound contrast agents. In: Goldberg BB (ed) Ultrasound contrast agents. Martin Dunits, pp 83–87

    Google Scholar 

  • Nino-Murcia M, Ralls PW, Jeffrey RB Jr, et al (1992) Color Doppler characterization of focal hepatic lesions. AJR 159:1195–1197

    Article  Google Scholar 

  • Nino-Murcia M, Olcott EW, Jeffrey RB Jr, et al (2000) Focal liver lesions: pattern-based classification scheme for enhancement at arterial phase CT. Radiology 215:746–751

    Google Scholar 

  • Numata K, Tanaka K, Kiba T, et al (1997) Use of hepatic tumor index on color Doppler sonography for differentiating large hepatic tumors. AJR 168:991–995

    Article  Google Scholar 

  • Van Leeuwen MS, Noordzij J, Feldberg MAM, et al (1996) Focal liver lesions: characterization with triphasic spiral CT. Radiology 201:327–336

    Google Scholar 

  • Quillin SP, Atilla S, Brown JJ, et al (1997) Characterization of focal hepatic masses by dynamic contrastenhanced MR imaging: fmdings in 311 lesions. Magn Reson Imaging 15:275–285

    Article  Google Scholar 

  • Bartolozzi C, Cioni D, Donati F, Lencioni R (2001) Focal liver lesions: MR imaging-pathologic correlation. Bur Radiol 11:1374–1388

    Google Scholar 

  • Harvey CJ, Albrecht T (2001). Ultrasound of focal liver lesions. Bur Radiol 11:2578–2593

    Google Scholar 

  • Ros PR, Menu Y, Vilgrain V, Mortele KJ, Terris B (2001) Liver neoplasms and tumor-like conditions. Bur Radiol 11 [5uppl2] S145-5165

    Google Scholar 

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  1. A. Martegani
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  2. L. Aiani
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  3. C. Borghi
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  4. L. Solbiati
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  5. M. Tonolini
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  6. A. Bellobuono
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  7. E. Leen
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  9. L. Cova
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Martegani, A. et al. (2003). Macro- and Microcirculation of Focal Liver. In: Contrast-Enhanced Ultrasound of Liver Diseases. Springer, Milano. https://doi.org/10.1007/978-88-470-2093-1_4

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  • DOI: https://doi.org/10.1007/978-88-470-2093-1_4

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  • Print ISBN: 978-88-470-2168-6

  • Online ISBN: 978-88-470-2093-1

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