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Ultrasound Contrast Agents

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Abstract

With the advent of new ultrasound contrastspecific scanning modes, the clinical potential of ultrasound contrast agents has been widely enhanced and the efficacy has been potentiated. Ultrasound contrast agents are based on microbubbles with a diameter of a few micrometers. Their efficacy was previously described mainly as echo enhancers for Doppler signals, and by enhancing the reflectivity of blood, the signal-to-noise ratio for Doppler signals can be enhanced and a clear Doppler trace may be obtained in otherwise difficult to scan patients.

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References

  • Agati L, Funaro S, Veneroso G, Volponi C, De Maio F, Madonna MP, Fedele F (2001) Non-invasive assessment of myocardial perfusion by intravenous contrast echocardiography: state of the art. Ital Heart J 2:403–437

    Google Scholar 

  • Barnhart J, Levene H, Villapando E, et al (1990) Characteristics of Albunex, air-filled albumin microspheres for echocardiography. Invest Radiol 25:162–164

    Google Scholar 

  • Basilico R, Blomley MJ, Harvey CJ, Filippone A, Heckemann RA, Eckersley RJ, Cosgrove DO. (2002) Which continuous US scanning mode is optimal for the detection of vascularity in liver lesions when enhanced with a second generation contrast agent? Eur J Radiol 41:184–191

    Article  Google Scholar 

  • Bauer A, Blomley M, Leen E, Cosgrove D, Schlief R (1999 ) Liver-specific imaging with SHU 563A: diagnostic potential of a new class of ultrasound contrast media. Eur Radiol 9 Suppl 3:S349–352

    Article  Google Scholar 

  • Bogdahn U, Holscher T, Rosin L, Gotz B, Schlachetzki F (1999) Contrast enhanced transcranial and extracranial duplex sonography: preliminary results of a multicenter phase II/III study with SonoVuetrade mark. Echocardiography 16:761–766

    Article  PubMed  Google Scholar 

  • Cohen JL, Cheirif J, Segar DS (1998) Improved left ventricular endocardial border delineation and opacification with OPTISON (FS069), a new echocardiographic contrast agent. Results of a phase III Multicenter Trial. J Am Coli Cardiol 32:746–752

    Google Scholar 

  • Dittrich HC, Bales GL, Kuvelas T (1995) Myocardial contrast echocardiography in experimental coronary artery occlusion with a new intravenously administered contrast agent. J Am Soc Echocardiogr 8:465–474

    Article  Google Scholar 

  • Dhond MR, Nguyen TT, Dolan C, Pulido G, Bommer WJ (2000) Ultrasound-enhanced thrombolysis at 20 kHz with air-filled and pertluorocarbon-filled contrast biospheres. J Am Soc Echocardiogr 13:1025–1029

    Article  Google Scholar 

  • Gramiak R, Shah PM (1968) Echocardiography of the aortic root. Invest Radiol 3:356–366

    Article  Google Scholar 

  • Kitzman DW, Goldman ME, Gillam LD, Cohen JL, Aurigemma GP, Gottdiener JS (2000) Efficacy and safety of the novel trasound contrast agent perflutren (Definity) in patients with suboptimal baseline left ventricular echocardiographic images. Am J Cardiol 86:669–674

    Article  PubMed  CAS  Google Scholar 

  • Leen E, Angerson WJ, Yarmenitis S, Bongartz G, Blomley M, Del Maschio A, Summaria V, Maresca G, Pezzoli C, Llull JB (2002) Multi-centre clinical study evaluating the efficacy of Sono Vue (BR1), a new ultrasound contrast agent in Doppler investigation of focal hepatic lesions. Eur J Radiol 41:200–206

    Article  Google Scholar 

  • Nanda NC, Wistran DC, Karlsberg RP, Hack TC, Smith WB, Foley DA, Picard MH, Cotter B (2002) Multicenter evaluation of SonoVue for improved endocardial border delineation. Echocardiography 19:27–36

    Article  Google Scholar 

  • Ophir J, Parker KJ (1989) Contrast agents in diagnostic ultrasound. Ultrasound Med Biol 15:319–333

    Article  Google Scholar 

  • Pelura TJ (1998) Clinical experience with AF0150 (Imagent US), a new ultrasound contrast agent. Acad Radiol 5 [Suppl 1]:S69–71

    Article  PubMed  Google Scholar 

  • Rosenberg ML, Carpenter AP (2002) Contrast material-enhanced abdominal US examinations with DMP 115 (DEFINITY) provides additional diagnostic information with potential for changes in patient management. Acad Radiol 9 [Suppl 1]:S243–245

    Article  Google Scholar 

  • Schneider M (1999) Characteristics of SonoVue. Echocardiography 16:743–746

    Article  PubMed  Google Scholar 

  • Schwarz KQ, Becher H, Schimpfky C, Vorwerk D, Bogdahn U, Schlief R (1994) A Study of the magnitude of Doppler enhancement with SH U 508 A in multiple vascular regions. Radiology 193:195–201

    Google Scholar 

  • Solbiati L, Tonolini M, Cova L, Goldberg SN (2001) The role of contrast-enhanced ultrasound in the detection of focal liver leasions. Eur Radiol U [Stippl 3]:E15–26

    Google Scholar 

  • Unger E, Shen DK, Fritz T, Lund P, Wu GL, Kulik B, DeYoung D, Standen J, Ovitt T, Matsunaga T (1993) Gas-filled liposomes as echocardiographic contrast agents in rabbits with myocardial infarcts. Invest Radiol 28:1155–1159

    Article  Google Scholar 

Download references

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© 2003 Springer-Verlag Italia

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Bauer, A., Solbiati, L. (2003). Ultrasound Contrast Agents. In: Contrast-Enhanced Ultrasound of Liver Diseases. Springer, Milano. https://doi.org/10.1007/978-88-470-2093-1_2

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  • DOI: https://doi.org/10.1007/978-88-470-2093-1_2

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2168-6

  • Online ISBN: 978-88-470-2093-1

  • eBook Packages: Springer Book Archive

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