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Gut Infections: Etiopathogenetic and Clinical Remarks

  • Daniele Dionisio

Abstract

In approximately 30% of human immunodeficiency virus (HIV)-infected diarrheic patients, no opportunistic infections can be detected [1]. These cases are often labeled as HIV enteropathy or HIV colitis and may be associated with a series of functional and histopathological gut alterations that include villous atrophy, abnormal lipid accumulation, enterocyte cytoplasmic vacuolation, crypt epithelial cell apopto- sis, lamina propria inflammation, impaired gastric acid, and intrinsic factor secretion, malabsorption, and dysfunctions in intestianl immunoglobulin production [1, 2]. Moreover, in 30%–70% of all patients, HIV was found within lymphocytes and macrophages in intestinal lymphoid tissue [1, 3–5]. In addition, HIV was isolated from enterocytes and colonic cells, as well as from enterochromaffin cells in small-bowel mucosa and in colonic ulcers or in areas of colonic infammation [3, 6].

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Visceral Leishmaniasis Acquire Immune Deficiency Syndrome Acquire Immunodeficiency Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • Daniele Dionisio

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