Abstract
The past 10 years have provided a series of well-designed clinical trials to study the effect of the implantable cardioverter defibrillator (ICD) in patients at high risk of sudden death. These studies have been carried out on both sides of the Atlantic. Patient populations have been recruited both from post-event populations and from pre-event populations judged to be at high enough risk to warrant prophylactic ICD implantation. The results of both categories of trial have been remarkably similar. Interestingly, the primary prevention studies were both initiated first and have shown more positive impact of ICD implantation on survival than the secondary prevention trials.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Moss AJ, Hall WJ, Cannom DS, Daubert JP, Higgins SL, Klein H, Levine JH, Saksena S, Waldo AL, Wilber D, Brown MW, Heo M, and the other MADIT investigators (1996) Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. N Engl J Med 335:1933–1940
Moss AI, Fadi Y, Zareba W, Cannom DS, Hall WJ, for the Multicenter Automatic Defibrillator Implantation Trial Research Group (2001) Survival benefit with an implanted defibrillator in relation to mortality risk in chronic coronary heart disease. Am J Cardiol 88:516–520
Buxton AE, Lee KL, Fisher JD, Josephson ME, Prystowsky EN, Hafley G (1999) A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial (MUSTT) Investigators. N Engl J Med 341:1882–1890
Moss AJ, Zareba W, Hall J, Klein H, Wilber DJ, Cannom DS, Daubert JP, Higgins SL, Brown MW, Andrews ML, for the MADIT-II Investigators (2002) Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 346:877–883
Zareba W (2002) Presented at NASPE’s 23rd Annual Scientific Sessions in San Diego on 11 May, 2002 in the Late Breaking Trial Session on MADIT II
Bansch D, Antz M, Boczor S, Volkner M, Tebbenjohanns J, Seidl K, Block M, Gietzen F, Berger J, Kuck KH, for the CAT investigators (2002) Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT). Circulation 105:1453–1458
Bristow MR, Feldman AM, Saxon LA, for the COMPANION Steering Committee and COMPANION Clinical Investigators (2000) Heart failure management using implantable devices for ventricular resynchronization: comparison of medical therapy, pacing, and defibrillation in chronic heart failure (COMPANION) trial. J Card Fail 6:276–285
Cleland JGF, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Klein W, Tavazzi L, on behalf of the CARE-HF study steering committee and investigators (2001) The CARE-HF study (Cardiac REsynchronisation in Heart Failure study): rationale, design and end-points. Eur J Heart Fail 3:481–489
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Italia
About this paper
Cite this paper
Cannom, D.S. (2003). A Review of the SCD-HEFT, COMPANION, and CARE-HF Trials. In: Gulizia, M. (eds) New Advances in Heart Failure and Atrial Fibrillation. Springer, Milano. https://doi.org/10.1007/978-88-470-2087-0_59
Download citation
DOI: https://doi.org/10.1007/978-88-470-2087-0_59
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2169-3
Online ISBN: 978-88-470-2087-0
eBook Packages: Springer Book Archive