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Biventricular Cardiac Resynchronization in Moderate-to-Severe Heart Failure: Analysis of Hospital Costs and Clinical Effectiveness (Brescia Study)

  • A. Curnis
  • F. Caprari
  • G. Mascioli
  • L. Bontempi
  • A. Scivales
  • F. Bianchetti
  • S. Nodari
  • L. Dei Cas
Conference paper

Abstract

Heart failure is a chronic condition of complex physiopathologic origin which involves escalating clinical costs [1-3]. Cardiac resynchronization therapy is a novel treatment for the one in every six heart failure patients whose condition is refractory to optimized drug treatment, with evidence of ventricular dysynchrony which leads to a deterioration of hemodynamics and a higher risk of death [4-7]. In such hearts the regions which activate in advance will experience or receive a lower afterload, and the rapid presystolic contraction does not convert into a rise in pressure, because the other parts of the myocardium are still inactive. As a consequence, most myocardial activity is wasted in transferring the ejection from one part of the heart to another. This results in a lengthening of the ventricular pre-ejection period, a reduction of the contraction and the relaxation period, a reduction of the ejection fraction, and a rise in mitral regurgitation.

Keywords

Heart Failure Cardiac Resynchronization Therapy Biventricular Pace Left Ventricular Lead Cardiology Ward 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • A. Curnis
    • 1
  • F. Caprari
    • 2
  • G. Mascioli
    • 1
  • L. Bontempi
    • 1
  • A. Scivales
    • 2
  • F. Bianchetti
    • 1
  • S. Nodari
    • 1
  • L. Dei Cas
    • 1
  1. 1.Department of CardiologyUniversity and Spedali Civili of BresciaBrescia
  2. 2.Fondazione Medtronic ItaliaMilanItaly

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