Selection of Patients for Cardiac Resynchronization Therapy

  • D. Gras
  • J. P. Cebron
  • P. Brunel
  • B. Leurent
  • Y. Banus
Conference paper


The epidemiologic data recently published with regard to congestive heart failure represent a strong incentive to mobilize all treatment options available. Despite remarkable advances, medical therapy suffers from serious limitations, as does, when all else has failed, cardiac transplantation. In this context, cardiac resynchronization therapy (CRT) has recently been introduced with, as a first objective, the relief of cardiac symptoms refractory to optimal medical therapy [1-4]. Acute hemodynamic studies first demonstrated that CRT could improve left ventricular mechanical function, increase cardiac index, and decrease intrapulmonary pressures [5-8]. These favorable effects were associated with a decrease in myocardial oxygen consumption [9], thus indicating reorganization of the segmental left ventricular contraction sequence and ultimately improved global ventricular function, instead of an increase in contractility at a cellular level.


Left Ventricular Filling Biventricular Pace Global Ejection Fraction Atrioventricular Delay Left Ventricular Global Ejection Fraction 
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Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • D. Gras
    • 1
  • J. P. Cebron
    • 1
  • P. Brunel
    • 1
  • B. Leurent
    • 1
  • Y. Banus
    • 1
  1. 1.Unité de Soins et de Cardiologie InterventionnellePolyclinique Saint HenriNantesFrance

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