ACE-Inhibitors, β-Blockers, Spironolactone: Do We Need Many More Drugs to Treat Chronic Heart Failure?
Over the last two decades, considerable insights into the pathophysiology of chronic congestive heart failure (HF) have been gained to suggest that the overstimulation of biologically active pathways - primarily the reninangiotensin-aldosterone and sympathoadrenergic systems - may play a key role in determining the progression of the syndrome . Supporting this concept, a large body of evidence has been accumulated to show that drugs possessing the ability to counteract these up-regulated neuroendocrine mechanisms may represent an effective therapeutic strategy to improve the course of the disease [2-7].
KeywordsHeart Failure Chronic Heart Failure Heart Failure Patient Brain Natriuretic Peptide Chronic Congestive Heart Failure
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