Cortistatin: Not Simply a Natural Somatostatin Analogue

  • R. Deghenghi
  • F. Broglio
  • F. Prodam
  • C. Gottero
  • M. Papotti
  • G. Muccioli
  • E. Ghigo


Cortistatin (CST) is a recently described peptide mostly expressed in cerebral cortex and hippocampus, but also in peripheral tissues such as fetal heart and lung, prostate, colon and the immune system (de Lecea et al., 1997a, de Lecea et al., 1997b; Fukusumi et al., 1997; Spier and de Lecea, 2000; Dalm et al., 2003). Pre-pro-CST shows high structural homology with pre-pro-somatostatin (pre-pro-SST), particularly in the carboxyl terminus from which SST-14 and SST-28 are enzymatically processed ( Spier and de Lecea, 2000). Interestingly, rat pre-pro-CST may also be cleaved to pro-CST from which the two mature products CST-14 and CST-29 can be generated in rats (de Lecea et al., 1996; Spier and de Lecea, 2000) and CST-17 and CST-29 in humans (de Lecea et al., 1997a; Fukusumi et al., 1997; Spier and de Lecea, 2000). CST-14 shares 11 of the 14 amino acid residues with SST-14, although these peptides are encoded by distinct genes (de Lecea et al., 1996 Spier and de Lecea, 2000).


Growth Hormone Ghrelin Level Growth Hormone Response Growth Hormone Secretagogue Growth Hormone Secretagogue Receptor 
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Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • R. Deghenghi
  • F. Broglio
  • F. Prodam
  • C. Gottero
  • M. Papotti
  • G. Muccioli
  • E. Ghigo

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