Skip to main content

Investigation of LHRH Receptor Involvement in Melanoma Growth and Progression

  • Conference paper
Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance

Abstract

The hypothalamic decapeptide luteinizing hormone-releasing hormone (LHRH) is the prime controller of reproductive function (Fink, 1988). It performs this function, after being secreted from the hypothalamus into the hypophysial portal circulation, by binding and activating specific receptors on gonadotrophs (Stojilkovic et al, 1994).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albino A.P., Reed J.A. and McNutt N.S. (1997). Molecular biology of cutaneous malignant melanoma. In Cancer Principles and Practice of Oncology, 5th edn, eds. De Vita V.T., Hellman S., Rosenberg S.A. Philadelphia, Lippincott-Raven.

    Google Scholar 

  • Breslow A. (1978). The surgical treatment of stage I cutaneous melanoma. Cancer Treat Rev, 5, 195–198.

    Article  PubMed  CAS  Google Scholar 

  • Chatzaki E., Bax C.M.R., Eidne K.A., Anderson L., Grudzinskas J.G. and Gallagher C.J. (1996). The expression of gonadotropin releasing hormone and its receptor in endometrial cancer and its relevance as an autocrine growth factor. Cancer Res, 56, 2055–2065.

    Google Scholar 

  • Conn P.M. and Crowley W.F. Jr. (1994). Gonadotropin-releasing hormone and its analogs. Ann Rev Med, 45, 391–405.

    Google Scholar 

  • Danny W.A. and Wilson W.R. (2000). Tirapazamine: a bioreductive anticancer drug that exploit tumor hypoxia. Expert Opin Investig Drug, 9, 2889–2901.

    Article  Google Scholar 

  • Dondi D., Limonta P., Moretti R.M., Montagnani Marelli M., Garattini E. and Motta M. (1994). Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory loop. Cancer Res, 54, 4091–4095.

    PubMed  CAS  Google Scholar 

  • Dondi D., Moretti R.M., Montagnani Marelli M., Pratesi G., Polizzi D., Milani M., Motta M. and Limonta P.(1998). Growth inhibitory effects of luteinizing hormone-releasing hormone (LHRH) agonists on xenografts of the DU 145 human androgen-independent prostate cancer cell line in nude mice. Int J Cancer, 76, 506–511.

    Article  PubMed  CAS  Google Scholar 

  • Emons G. and Schally A.V. (1994). The use of luteinizing hormone releasing hormone agonists and antagonists in gynaecologi cal cancers. Hum Reprod, 9, 1364–1379.

    PubMed  CAS  Google Scholar 

  • Emons G., Ortmann O., Becker M., Irmer G., Springer B., Laun R., Holzel E, Schulz K.D. and Schally A.V. (1993). High affinity binding and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines. Cancer Res, 54, 5439–5446.

    Google Scholar 

  • Emons G., Weiss S., Ortmann O., Grundker C. and Schulz K.D. (2000). LHRH might act as a negative autocrine regulator of proliferation of human ovarian cancer. Eur J Endocrinol, 142, 665–670.

    Article  PubMed  CAS  Google Scholar 

  • Fink G. (1988). Gonadotropin secretion and its control. In The Physiology of Reproduction, eds. Knobil E. and Kneill J.D., pp. 1349-1377. NewYork, Raven Press.

    Google Scholar 

  • Halaban R. (1996). Growth factors and melanoma. Semin Oncol, 23, 673–681.

    PubMed  CAS  Google Scholar 

  • Herlyn M., Clark W.H., Rodeck U., Mancianti M.L., Jambrosic J. and Koprowski H. (1987). Biology of tumor progression in human melanocytes. Lab Invest, 56, 461–474.

    PubMed  CAS  Google Scholar 

  • Hofmann U.B., Westphal J.R., van Muijen G.N.P. and Ruiter D.J. (2000). Matrix metalloproteinases in human melanoma. J Invest Dermatol, 115, 337–344.

    Article  PubMed  CAS  Google Scholar 

  • Hwu W.J. (2000). New approaches in the treatment of metastatic melanoma: thalidomide and temozolomide. Oncology, 14, 25–28.

    PubMed  CAS  Google Scholar 

  • Imai A., Ohno T., Iida K., Fuseya T., Furui T. and Tamaya T. (1994). Gonadotropin-releasing hormone receptors in gynecological tumors. Cancer, 74, 2555–2561.

    Article  PubMed  CAS  Google Scholar 

  • Kakar S.S., Musgrove L.C., Devor D.C., Sellers J.C. and Neill J.D. (1992).Cloning, sequencing and expression of human gonadotropin-releasing hormone (GnRH) receptor. Biochem Biophys Res Commun, 189, 289–295.

    Article  PubMed  CAS  Google Scholar 

  • Kakar S.S., Grizzle W.E. and Neill J.D. (1994). The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. Mol Cell Endocrinol, 106, 145–149.

    Article  PubMed  CAS  Google Scholar 

  • Kalra S.P. (1993). Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocr Rev, 14, 507–538.

    PubMed  CAS  Google Scholar 

  • Karande A.A., Rajeshwari K., Schol D.J. and Hilgers J.H.M. (1995). Establishment of immunological probes to study human gonadotropin-releasing hormone receptors. Mol Cell Endocrinol, 114, 51–56.

    Article  PubMed  CAS  Google Scholar 

  • Kottler M.L., Starzec A., Carre M.C., Lagarde J.P., Martin A. and Counis R. (1997). The genes for gonadotropin-releasing hormone and its receptor are expressed in human breast with fibrocystic disease and cancer. Int J Cancer, 71, 595–599.

    Article  PubMed  CAS  Google Scholar 

  • Lazar-Molnar E., Hegyesi H., Toth S. and Falus A. (2000). Autocrine and paracrine regulation by cytokines and growth factors in melanoma. Cytokine, 12, 547–554.

    Article  PubMed  CAS  Google Scholar 

  • Limonta P., Dondi D., Moretti R.M., Maggi R. and Motta M. (1992). Antiproliferative effects of luteinizing hormone-releasing hormone agonists on the human prostatic cancer cell line LNCaP. J Clin Endocrinol Metab, 75, 207–212.

    Article  PubMed  CAS  Google Scholar 

  • Limonta P., Dondi D., Moretti R.M., Fermo D., Garattini E. and Motta M. (1993). Expression of luteinizing hormone-releasing hormone mRNA in the human prostatic cancer cell line LNCaP. J Clin Endocrinol Metab, 76, 797–800.

    Article  PubMed  CAS  Google Scholar 

  • Lu C. and Kerbel R.S. (1994). Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. Curr Opin Oncol, 6, 212–220.

    Article  PubMed  CAS  Google Scholar 

  • Mackie R.M. (1998) Incidence, risk factors and prevention of melanoma. Eur J Cancer, 34 (Suppl 3), S3-S6.

    Article  PubMed  Google Scholar 

  • Meyer T. and Hart I.R. (1998).Mechanisms of tumor metastasis. Eur J Cancer, 34, 214–221.

    Article  PubMed  CAS  Google Scholar 

  • Natali P.G., Nicotra M.R., Bartolazzi A., Cavaliere R. and Bigotti A. (1993). Integrin expression in cutaneous malignant melanoma: associ ation of the α3/β1 heterodimer with tumor progression. Int J Cancer, 54, 68–72.

    Article  PubMed  CAS  Google Scholar 

  • Oikawa M., Dargan C., Ny T. and Hsueh A.J.W. (1990). Expression of gonadotropinreleasing hormone and prothymosin-a messenger ribonucleic acid in the ovary. Endocrinology 127, 2350–2356.

    Article  PubMed  CAS  Google Scholar 

  • Parkin D.M., Pisani P. and Ferlay J. (1999). Global cancer statistics. CA Cancer J Clin, 49, 33–64.

    Article  PubMed  CAS  Google Scholar 

  • Schally A.V. (1994). Hypothalamic hormones from neuroendocrinology to cancer therapy. Anticancer Drugs, 5, 115–130.

    Article  PubMed  CAS  Google Scholar 

  • Shih I.M. and Herlyn M. (1993). Role of growth factors and their receptors in the development and progression of melanoma. J Invest Dermatol, 100, S196–S203.

    Google Scholar 

  • Shih I.M. and Herlyn M. (1994). Autocrine and paracrine roles for growth factors in melanoma. In Vivo, 8, 113–123.

    PubMed  CAS  Google Scholar 

  • Stojilkovic S.S., Reinhart J. and Catt K.J. (1994).Gonadotropin-releasing hormone receptors. Structure and signal transduction pathways. Endocr Rev, 15, 462–499.

    PubMed  CAS  Google Scholar 

  • Stojilkovic S.S. and Catt K.J. (1995). Expression and signal transduction pathways of gonadotropin releasing hormone receptors. Recent Prog Horm Res, 30, 161–205.

    Google Scholar 

  • van Groeninghen JC, Kiesel L, Winkler D and Zwirner M (1998). Effects of luteinizing hormone-releasing hormone on nervous-system tumours. Lancet, 352, 372–373.

    Article  PubMed  CAS  Google Scholar 

  • Wormald PJ, Eidne KA and Millar RP (1985). Gonadotropin-releasing hormone receptors in human pituitary: ligand structural requirements, molecular size, cationic effects. J Clin Endocrinol and Metab, 61, 1190–1194.

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Italia

About this paper

Cite this paper

Marelli, M.M., Moretti, R.M., Limonta, P. (2003). Investigation of LHRH Receptor Involvement in Melanoma Growth and Progression. In: Müller, E.E. (eds) Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance. Springer, Milano. https://doi.org/10.1007/978-88-470-2085-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2085-6_5

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2170-9

  • Online ISBN: 978-88-470-2085-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics