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Endocrine and Nonendocrine Actions of Ghrelin and GHS: State of the Art in Clinic Research

  • A. Benso
  • F. Broglio
  • C. Gottero
  • F. Prodam
  • S. Destefanis
  • M. Volante
  • P. Cassoni
  • F. Catapano
  • E. Tanabra
  • L. Filtri
  • R. Deghenghi
  • E. Arvat
  • M. Papotti
  • G. Muccioli
  • E. Ghigo
Conference paper

Abstract

Ghrelin, a 28-amino-acid peptide predominantly produced by the stomach, displays strong GH-releasing activity mediated by the activation of the GH secretagogue (GHS) receptor (GHS-R) 1a, which has been shown to be specific for a family of synthetic peptidyl and nonpeptidyl GHS (Smith et al., 1997; Kojima et al., 2001b; Muccioli et al., 2002). These synthetic molecules were invented more than 20 years ago and their strong GH-releasing activity even after oral administration suggested their potential usefulness as a new tool for the diagnosis and treatment of GH deficiency in childhood and somatopause in aging Smith et al., 1997; Muccioli et al., 2002). The discovery of ghrelin as a natural ligand of the GHS-R1a represented a true turning po int in our understanding the control of the GH/IGF-1 axis, but it is already clear that ghrelin is much more than simply a natural GHS.

Keywords

Growth Hormone Ghrelin Level Growth Hormone Response Stimulate Insulin Secretion Gastric Carcinoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • A. Benso
  • F. Broglio
  • C. Gottero
  • F. Prodam
  • S. Destefanis
  • M. Volante
  • P. Cassoni
  • F. Catapano
  • E. Tanabra
  • L. Filtri
  • R. Deghenghi
  • E. Arvat
  • M. Papotti
  • G. Muccioli
  • E. Ghigo

There are no affiliations available

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