Abstract
Growth hormone secretagogues (GHS) consist of a series of small enkephalin derived peptides identified as growth hormone-releasing peptides (GHRPs) (Bowers, 1993) and non-peptidyl derivatives modeled from GHRPs (Smith et al., 1997). To this class of compounds is recently added a new member, ghrelin, an endogenous 28 amino acid polypeptide isolated from the stomach (Kojima et al., 1999). GHS share a common activity in stimulating the release of growth hormone (GH) from the pituitary in several animal species and in man (Ghigo et al., 2001). The GH release is mediated through the binding of GHS to a G protein-coupled receptor identified by expression cloning as GHS-Ria or ghrelin receptor, for which mRNA expression as well as protein receptor localization are mainly confined to the hypothalamus and the pituitary (Howard et al., 1996).
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Ong, H., Lamontagne, D., Demers, A., Marleau, S. (2003). Physiological Function of Growth Hormone Secretagogue Receptors in the Cardiovascular System. In: Müller, E.E. (eds) Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance. Springer, Milano. https://doi.org/10.1007/978-88-470-2085-6_12
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DOI: https://doi.org/10.1007/978-88-470-2085-6_12
Publisher Name: Springer, Milano
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