Twenty-five Years of Endocrine Oncology with Analogs of Hypothalamic Peptides: An Overview

  • A. V. Schally
Conference paper


In this chapter I will try to report to you what I have been doing for the past 25 years and what advancements in oncology have emanated so far from the work on the hypothalamus. The discovery of hypothalamic hormones, especially luteinizing hormone-releasing hormone (LHRH) and somatostatin, has led to practical clinical use of their analogs in the field of cancer treatment. LHRH, somatostatin, growth hormone-releasing hormone (GHRH), their mRNAs and their receptors are found in diverse tumors (Schally et al., 2001a, Schally et al., 2001b). Mammalian bombesin-like peptides, such as gastrin-releasing peptide (GRP) and neuromedin B, are likewise present in various tumors, and appear to produce mitogenic effects (Cuttitta, 1985; Sunday et al., 1988; Schally et al., 2001a). Antagonists of bombesin/GRP can be also used for the development of new methods for treatment of various tumors. In addition we have synthesized and evaluated cytotoxic analogs of LHRH, somatostatin and bombesin that can be targeted to various tumors. Moreover, we have made antagonists of GHRH, not discussed here. This chapter reviews some selected experimental and clinical findings on the use of analogs of LHRH, somatostatin and bombesin for treatment of various cancers.


Nude Mouse Human Prostate Cancer Small Cell Lung Carcinoma LHRH Agonist Human Epithelial Ovarian Cancer 
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  • A. V. Schally

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