Riassunto
Esistono diverse condizioni fisiopatologiche in grado di determinare alterazioni della cascata coagulativa o anche solo importanti alterazioni dei dati di laboratorio relativi all’emostasi. La fluidità del sangue all’interno dei vasi, così come la formazione di un coagulo, è il risultato della fisiologica interazione tra proteine ad attività pro e anticoagulante con le piastrine e le cellule endoteliali. Una visione schematica della cascata coagulativa, tradizionalmente suddivisa tra via “intrinseca”, “estrinseca” e “comune”, è sicuramente utile a fini didattici, ma è ormai noto che si tratta, invece, di un processo dinamico, con la continua interazione di feedback positivi tra trombina ed elementi a monte della formazione del coagulo.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliografia
Nichols DG (2008) Roger’s Textbook of Pediatric Intensive Care. Lippincott Williams & Wilkins, Philadelphia, PA
Baudo F (2002) Coagulazione ed infiammazione: dalla fisiopatologia alla clinica. Minerva Anestesiol 68:443–444
Esmon CT (2004) Crosstalk between inflammation and thrombosis. Maturitas 47:305–314
Hayward CPM, Rao AK, Cattaneo M (2006) Congenital platelet disorders: overview of their mechanisms, diagnostic evaluation and treatment. Hemophilia 12:128–136
Dempfle CE (2004) Coagulopathy and sepsis. Thromb Haemost 91:213–224
Michelson AD (2003) How platelets work: Platelet function and dysfunction. J Thromb Thrombolysis 16:7–12
Manno CS (2005) Management of bleeding disorders in children. Hematology 1:416–422
Parker RI (2005) Neonatal thrombosis, hemostasis, and platelet disorders. In: Spitzer AR (ed) Intensive Care of the Fetus & Neonate, 2nd Edn. Elselvier Mosby, Philadelphia, PA
Bussel J (2001) Alloimmune thrombocytopenia in the fetus and newborn. Semin Hematol 27:245–252
Lowe E, Buchanan G (2002) Idiopathic thrombocytopenic purpura diagnosed during the second decade of life. J Pediatr 141:253–258
Nurden AT, Phillips DR, George JN (2006) Platelet membrane glycoproteins: Historical perspectives. J Thromb Haemost 4:3–9
Brady KM, Easley RB, Tobias JD (2006) Recombinant factor VIIa (rFVIIa) treatment in infants with hemorrhage. Pediatr Anaesth 16:1042–1046
Levi M, Toh CH, Thachil J, Watson HG (2009) Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Journal of Haematology 145:24–33
Khemani RG, Bart RD, Alonzo TAG et al (2009) Disseminated intravascular coagulation score is associated with mortality for children with shock. Int Care Med 35:327–233
Kajdacsy A, Balla Amaral C, Rubenfeld GD (2006) Year in review 2005: Critical Care-resource management. Critical Care 10:215 (doi:10.1186/cc4953)
Hermans PW, Hazelzet JA (2005) Plasminogen activator inibitor type 1 gene polymorphism and sepsis. Clin Infect Dis 41:S453–458
Esmon Charles T (2001) The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness. Critical Care 5:S7–S12
Bernard GR, Vincent JL, Laterre PF et al (2001) Efficacy and safety of recombinant activated protein C for severe sepsis. New Engl J Med 344:699–709
de Kleijn ED, de Groot R, Hack CE et al (2003) Activation of protein C following infusion of protein C concentrate in children with severe meningococcical sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study. Crit Care Med Jun 31:1839–1847
Ruggenenti P, Noris M, Remuzzi G (2001) Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kydney Int 60:831–846
Schneppenheim R, Greiner J (2006) Thrombosis in infant and children. Hematology 86–96
Raffini L (2008) Thrombophilia in children: Who to test, how, when, and why? Hematology 228–235
Goldenberg NA (2008) Thrombophilia states and markers of coagulation activation in the prediction of pediatric venous trhomboembolic outcomes: a comparative analysis with respect to adult evidence. Hematology 236–244
Young G (2008) New anticoagulants in children. Hematology 245–250
Mc Crory MC (2011) Thrombotic disease in critically ill children. Pediatr Crit Care Med 12:80–89
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Italia
About this chapter
Cite this chapter
Masciopinto, F., Landuzzi, V. (2012). Turbe dell’emostasi. In: Rianimazione in età pediatrica. Springer, Milano. https://doi.org/10.1007/978-88-470-2059-7_6
Download citation
DOI: https://doi.org/10.1007/978-88-470-2059-7_6
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2058-0
Online ISBN: 978-88-470-2059-7
eBook Packages: MedicineMedicine (R0)