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VAP (Ventilator Associated Pneumonia)

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Excerpta Anestesiologica

Riassunto

Per polmonite si intende la presenza di un infiltrato flogistico di origine infettiva nel parenchima polmonare. La polmonite che si osserva nei pazienti in terapia intensiva è per lo più dovuta all’aspirazione di microrganismi della flora orale, nasofaringea o gastrointestinale che raggiungono le vie aeree distali in situazioni di alterata difesa delle vie aeree superiori (trauma, coma, chirurgia) o in presenza di presidi come il tubo endotracheale o la cannula tracheostomica. Normalmente, infatti, le basse vie respiratorie sono mantenute sterili grazie a una varietà di meccanismi di difesa: la barriera anatomica rappresentata dalla glottide, il riflesso della tosse, la presenza delle secrezioni bronchiali associate al movimento ciliare, l’immunità umorale e cellulomediata e il sistema fagocitico dei macrofagi alveolari e dei neutrofili. La polmonite si verifica quando i microrganismi riescono a superare queste barriere e a raggiungere il parenchima polmonare per un difetto delle difese dell’ospite, per una particolare virulenza del microrganismo o per un inoculo di grande entità [1, 2].

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Bibliografia

  1. Chastre J, Fagon JY (2002) Ventilator-associated pneumonia. Am J Respir Crit Care Med 165:867–903

    Article  PubMed  Google Scholar 

  2. Torres A, Ewig S, Lode H et al (2009) Defining, treating and preventing hospital acquired pneumonia: European perspective. Intensive Care Med 35:9–29

    Article  PubMed  Google Scholar 

  3. American Thoracic Society (2005) Guidelines for the management of adults with hospitalacquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388–416

    Article  Google Scholar 

  4. Fagon JY, Chastre J (2005) Nosocomial pneumonia. In: Fink MP (ed) Textbook of critical care. Elsevier Saunders, Philadelphia, pp 663–677

    Google Scholar 

  5. Langer M, Cigada M, Mandelli M et al (1987) Early onset pneumonia: a multicenter study in intensive care units. Intensive Care Med 13:342–347

    Article  PubMed  CAS  Google Scholar 

  6. Vincent JL, Bihari DJ, Suter PM et al (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC international advisory committee. JAMA 274:639–644

    CAS  Google Scholar 

  7. Cross AS, Roup B (1981) Role of respiratory assistance devices in endemic nosocomial pneumonia. Am J Med 70:681–685

    Article  PubMed  CAS  Google Scholar 

  8. Langer M, Mosconi P, Cigada M et al (1989) Long-term respiratory support and risk of pneumonia in critically ill patients. Intensive Care Unit Group of Infection Control. Am Rev Respir Dis 140:302–305

    Article  PubMed  CAS  Google Scholar 

  9. Markowicz P, Wolff M, Djedaini K et al (2000) Multicenter prospective study of ventilator associated pneumonia during acute respiratory distress syndrome. Incidence, prognosis and risk factors. ARDS study group. Am J Respir Crit Care Med 161:1942–1948

    Article  PubMed  CAS  Google Scholar 

  10. Craven DE (2000) Epidemiology of ventilator-associated pneumonia. Chest 117:186S–187S

    Article  PubMed  CAS  Google Scholar 

  11. Kollef MH, Sherman G, Ward S et al (1999) Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115: 462–474

    Article  PubMed  CAS  Google Scholar 

  12. Rello J, Diaz E, Rodriguez A (2005) Etiology of ventilator-associated pneumonia. Clin Chest Med 26:87–95

    Article  PubMed  Google Scholar 

  13. Park DR (2005) The microbiology of ventilator-associated pneumonia. Respir Care 50:742–763

    PubMed  Google Scholar 

  14. Frutos-Vivar F, Esteban A, Apezteuguia C et al (2005) Outcome of mechanically ventilated patients who require a tracheostomy. Crit Care Med 33:290–298

    Article  PubMed  Google Scholar 

  15. Torres A, Ewig S (2004) Diagnosing ventilator-associated pneumonia. N Engl J Med 350:433–435

    Article  PubMed  CAS  Google Scholar 

  16. The Canadian Critical Care Trials Group (2006) A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med 355:2619–2629

    Article  Google Scholar 

  17. Dupont H, Mentec H, Sollet JP et al (2001) Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 27:355–362

    Article  PubMed  CAS  Google Scholar 

  18. Paul M, Soares-Weiser K, Leibovici L (2003) Beta lactam monotherapy versus beta lactamaminoglycoside combination therapy for fever with neutropenia: systematic review and metaanalysis. BMJ 326:1111–1115

    Article  PubMed  CAS  Google Scholar 

  19. Chastre J, Wolff M, Fagon JY et al (2003) Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 290:2588–2598

    Article  PubMed  CAS  Google Scholar 

  20. Cook D, De Jonghe B, Brochard L et al (1998) Influence of airway management on ventilator associated pneumonia: evidence from randomized trials. JAMA 279:781–787

    Article  PubMed  CAS  Google Scholar 

  21. Nathens AB, Marshall JC (1999) Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence. Arch Surg 134:170–176

    Article  PubMed  CAS  Google Scholar 

  22. De Smet AMGA, Kluytmans JAJW, Cooper BS et al (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360:20–31

    Article  PubMed  Google Scholar 

  23. Berra L, De Marchi L, Yu ZX et al (2004) Endotracheal tube coated with antiseptics decrease bacterial colonization of the ventilatory circuit, lungs and endotracheal tube. Anesthesiology 100:1446–1456

    Article  PubMed  CAS  Google Scholar 

  24. Kollef MH, Afessa B, Anzueto A et al (2008) Silver-coated endotracheal tubes and incidence of ventilator associated pneumonia: the NASCENT randomized trial. JAMA 300:805–813

    Article  PubMed  CAS  Google Scholar 

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Chiumello, D., Fossali, T. (2011). VAP (Ventilator Associated Pneumonia). In: Allaria, B. (eds) Excerpta Anestesiologica. Springer, Milano. https://doi.org/10.1007/978-88-470-2023-8_11

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  • DOI: https://doi.org/10.1007/978-88-470-2023-8_11

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2022-1

  • Online ISBN: 978-88-470-2023-8

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