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Immunoglobulins in Sepsis

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Anaesthesia, Pharmacology, Intensive Care and Emergency Medicine A.P.I.C.E.

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Abstract

For decades, intravenously administered immunoglobulin preparations (IvIg) have been extensively used in different categories of critical diseases, including sepsis, polyneuritis of different origins and myasthenia gravis (MG). From this short list, it is evident that IvIg have been administered either to boost or to downregulate patients’ immunologic response. These apparently opposing indications are a result of their pleiotropic effects on the immune system, which include: (a) immune response augmentation through an increase in opsonisation and phagocytosis and complement system activation; and (b) reduced inflammatory response via decreased production of tumour necrosis factor-α (TNF-α) and other inflammatory mediators and increased release of soluble receptors for a number of cytokines [1, 2]. This dual effect of IvIg makes them a valuable therapeutic tool either in the phase of full-blown inflammation or in the subsequent compensatory anti-inflammatory response syndrome (CARS) [3], which is associated with an overall reduction of the immunologic response [4].

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Authors
  1. G. Berlot
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  2. C. M. Vassallo
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  3. N. Busetto
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Editor information

Editors and Affiliations

  1. Department and School of Anaesthesia and Intensive Care, Catania University-Hospital, Catania, Italy

    Antonino Gullo

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© 2011 Springer-Verlag Italia

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Berlot, G., Vassallo, C.M., Busetto, N. (2011). Immunoglobulins in Sepsis. In: Gullo, A. (eds) Anaesthesia, Pharmacology, Intensive Care and Emergency Medicine A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2014-6_20

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  • DOI: https://doi.org/10.1007/978-88-470-2014-6_20

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2013-9

  • Online ISBN: 978-88-470-2014-6

  • eBook Packages: MedicineMedicine (R0)

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