Immunoglobulins in Sepsis

  • G. Berlot
  • C. M. Vassallo
  • N. Busetto
Conference paper


For decades, intravenously administered immunoglobulin preparations (IvIg) have been extensively used in different categories of critical diseases, including sepsis, polyneuritis of different origins and myasthenia gravis (MG). From this short list, it is evident that IvIg have been administered either to boost or to downregulate patients’ immunologic response. These apparently opposing indications are a result of their pleiotropic effects on the immune system, which include: (a) immune response augmentation through an increase in opsonisation and phagocytosis and complement system activation; and (b) reduced inflammatory response via decreased production of tumour necrosis factor-α (TNF-α) and other inflammatory mediators and increased release of soluble receptors for a number of cytokines [1, 2]. This dual effect of IvIg makes them a valuable therapeutic tool either in the phase of full-blown inflammation or in the subsequent compensatory anti-inflammatory response syndrome (CARS) [3], which is associated with an overall reduction of the immunologic response [4].


Septic Shock Severe Sepsis Innate Immune System Septic Patient Toxic Shock Syndrome 


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Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • G. Berlot
  • C. M. Vassallo
  • N. Busetto

There are no affiliations available

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